Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3794440..3795014 Replicon chromosome
Accession NZ_CP062122
Organism Pseudomonas sp. ADPe

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A5D8B5
Locus tag IG194_RS17125 Protein ID WP_058488309.1
Coordinates 3794649..3795014 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W5ISP5
Locus tag IG194_RS17120 Protein ID WP_009613188.1
Coordinates 3794440..3794655 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG194_RS17100 3789544..3790335 + 792 WP_058488307.1 ATP-binding cassette domain-containing protein -
IG194_RS17105 3790325..3791143 + 819 WP_009613191.1 ABC transporter permease subunit -
IG194_RS17110 3791323..3792159 + 837 WP_043268829.1 taurine dioxygenase -
IG194_RS17115 3792348..3794372 + 2025 WP_058488308.1 oligopeptide transporter, OPT family -
IG194_RS17120 3794440..3794655 + 216 WP_009613188.1 ribbon-helix-helix domain-containing protein Antitoxin
IG194_RS17125 3794649..3795014 + 366 WP_058488309.1 type II toxin-antitoxin system VapC family toxin Toxin
IG194_RS17130 3795002..3795727 - 726 WP_058488310.1 hypothetical protein -
IG194_RS17135 3795724..3795906 - 183 WP_043318704.1 hypothetical protein -
IG194_RS17140 3795903..3797051 - 1149 WP_058488311.1 PepSY domain-containing protein -
IG194_RS17145 3797059..3799470 - 2412 WP_058488312.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13376.45 Da        Isoelectric Point: 5.8613

>T173387 WP_058488309.1 NZ_CP062122:3794649-3795014 [Pseudomonas sp. ADPe]
MVKALFDTNVLIDYLNGHEQARDELRRYDDPAISIVTWMEVMIGATPATAAATRAFLDSFALVPLDAPVAERAVAVRQAL
RVKLPDAIIKASAEVQGRLLVTRNTRDFPVDDAGVRLPYRL

Download         Length: 366 bp

>T173387 NZ_CP080157:153328-153744 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8033.94 Da        Isoelectric Point: 4.7616

>AT173387 WP_009613188.1 NZ_CP062122:3794440-3794655 [Pseudomonas sp. ADPe]
MRTLVDIPAEHLEALNALGEQQQQSRAALIREAVAEYLVRHRRQDAEAAFGLWNGSAGDGLAYQEKVREEW

Download         Length: 216 bp

>AT173387 NZ_CP080157:153101-153331 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5D8B5

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D6Z2

References