Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2814053..2814558 Replicon chromosome
Accession NZ_CP062122
Organism Pseudomonas sp. ADPe

Toxin (Protein)


Gene name parE Uniprot ID W5IQ81
Locus tag IG194_RS12810 Protein ID WP_009614629.1
Coordinates 2814277..2814558 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1A5CZE2
Locus tag IG194_RS12805 Protein ID WP_058487882.1
Coordinates 2814053..2814280 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG194_RS12785 2810674..2811075 - 402 WP_058487878.1 GFA family protein -
IG194_RS12790 2811087..2811818 - 732 WP_058487879.1 phytanoyl-CoA dioxygenase family protein -
IG194_RS12795 2811815..2812741 - 927 WP_058487880.1 LysR family transcriptional regulator -
IG194_RS12800 2812816..2813772 - 957 WP_058487881.1 agmatinase -
IG194_RS12805 2814053..2814280 + 228 WP_058487882.1 CopG family ribbon-helix-helix protein Antitoxin
IG194_RS12810 2814277..2814558 + 282 WP_009614629.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IG194_RS12815 2814818..2815549 + 732 WP_058487883.1 RcnB family protein -
IG194_RS12820 2815590..2815871 - 282 WP_058487884.1 DUF2218 domain-containing protein -
IG194_RS12825 2815969..2816886 + 918 WP_058487885.1 LysR family transcriptional regulator -
IG194_RS12830 2816945..2817400 + 456 WP_058487886.1 GNAT family N-acetyltransferase -
IG194_RS12835 2817397..2818014 - 618 WP_058487887.1 DUF1826 domain-containing protein -
IG194_RS12840 2818014..2819216 - 1203 WP_058487888.1 zinc metallochaperone GTPase ZigA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10251.74 Da        Isoelectric Point: 6.4614

>T173386 WP_009614629.1 NZ_CP062122:2814277-2814558 [Pseudomonas sp. ADPe]
MSLQWTHKAAADLDGLYDHYVVLIGPEKALKAIQDVVGQVKALADLSLSSVGRPSEVPGVRELPLERWPYQAAYRVKGRD
VQILRIDSVDNPG

Download         Length: 282 bp

>T173386 NZ_CP080157:c148916-148611 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8341.38 Da        Isoelectric Point: 6.6405

>AT173386 WP_058487882.1 NZ_CP062122:2814053-2814280 [Pseudomonas sp. ADPe]
MTTVISFRADDALAKALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGLADANAGHLLPHAEIEAKWGPA

Download         Length: 228 bp

>AT173386 NZ_CP080157:c149136-148918 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5D1B8

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5CZE2

References