Detailed information of TA system TA173385

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 2281053..2281701
• Replicon: chromosome
• Accession: NZ_CP062122
• Organism: Pseudomonas sp. ADPe

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: IG194_RS10460
• Protein ID: WP_051878815.1
• Coordinates: 2281366..2281701 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: IG194_RS10455
• Protein ID: WP_043269347.1
• Coordinates: 2281053..2281373 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG194_RS10445	2277090..2278868	-	1779	WP_058487642.1	acyl-CoA dehydrogenase C-terminal domain-containing protein	-
IG194_RS10450	2279087..2280883	-	1797	WP_043319190.1	acyl-CoA dehydrogenase C-terminal domain-containing protein	-
IG194_RS10455	2281053..2281373	-	321	WP_043269347.1	helix-turn-helix domain-containing protein	Antitoxin
IG194_RS10460	2281366..2281701	-	336	WP_051878815.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IG194_RS10465	2281894..2283699	-	1806	WP_058487643.1	phenylacyl-CoA dehydrogenase	-
IG194_RS10470	2284004..2284231	-	228	WP_009615495.1	hypothetical protein	-
IG194_RS10475	2284298..2284987	-	690	WP_009615494.1	dethiobiotin synthase	-
IG194_RS10480	2285138..2285944	-	807	WP_058487644.1	malonyl-ACP O-methyltransferase BioC	-
IG194_RS10485	2285937..2286662	-	726	WP_058487645.1	alpha/beta fold hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (7-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12382.95 Da
• Isoelectric Point: 7.0613

>T173385 WP_051878815.1 NZ_CP062122:c2281701-2281366 [Pseudomonas sp. ADPe]
MGSSKRDLLDMPDDVQDVFGFALHQAQEGGKHPQTKPMKGFSGAGVLEVVEDHDGDTYRAVYTVKFARAVYALHCFQKKS
TKGIETPQHDLELIRKRLKDAQAHAKSVEND

Nucleotide

• Length: 336 bp

>T173385 NZ_CP080157:99441-99839 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11579.49 Da
• Isoelectric Point: 10.4649

>AT173385 WP_043269347.1 NZ_CP062122:c2281373-2281053 [Pseudomonas sp. ADPe]
MIEFEEGSGNVYADLGRADAGEMQVKARLASKIGSIIKARHLTQTQAAEILGLPQPKVSDMLRGKFRGISEAKMIDCLAR
LGRDVQIVVKAAPRSRREGRVEVVFA

Nucleotide

• Length: 321 bp

>AT173385 NZ_CP080157:99214-99441 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA