Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2263646..2264265 Replicon chromosome
Accession NZ_CP062122
Organism Pseudomonas sp. ADPe

Toxin (Protein)


Gene name hicA Uniprot ID A0A1A5CXG3
Locus tag IG194_RS10395 Protein ID WP_058487638.1
Coordinates 2264083..2264265 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID W5J3H2
Locus tag IG194_RS10390 Protein ID WP_009615524.1
Coordinates 2263646..2264050 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG194_RS10375 2261613..2262797 + 1185 WP_058487636.1 Fic family protein -
IG194_RS10380 2262820..2263245 - 426 WP_176707199.1 type II toxin-antitoxin system VapC family toxin -
IG194_RS10385 2263242..2263496 - 255 WP_058487637.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IG194_RS10390 2263646..2264050 - 405 WP_009615524.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IG194_RS10395 2264083..2264265 - 183 WP_058487638.1 type II toxin-antitoxin system HicA family toxin Toxin
IG194_RS10400 2264724..2265212 + 489 WP_009615520.1 hypothetical protein -
IG194_RS10405 2265512..2265670 - 159 WP_009615518.1 YqaE/Pmp3 family membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2255762..2265670 9908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6962.08 Da        Isoelectric Point: 12.2925

>T173384 WP_058487638.1 NZ_CP062122:c2264265-2264083 [Pseudomonas sp. ADPe]
MRSREIMELIRADGWFLVEVKGSHHQFRHFTKQGRVTVPHPRSNLPIGTVNSILRQAGLR

Download         Length: 183 bp

>T173384 NZ_CP080157:c90485-90336 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14532.23 Da        Isoelectric Point: 4.5714

>AT173384 WP_009615524.1 NZ_CP062122:c2264050-2263646 [Pseudomonas sp. ADPe]
MKFPVVLHKDADSDYGVTIPDVPGCFSAGGTVSQALENVQEALALHFEGLVADGETLPQAQEVDTHMGNPDYAGGVWAVV
DFDVTPYLGKAVRFNASLPENLLQRIDERVKRDHRYASRSGFLATAALRELSSN

Download         Length: 405 bp

>AT173384 NZ_CP080157:90529-90590 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5CXG3

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5CY34

References