Detailed information of TA system TA173382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1297881..1299020
• Replicon: chromosome
• Accession: NZ_CP062122
• Organism: Pseudomonas sp. ADPe

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A1A5DAJ3
• Locus tag: IG194_RS05915
• Protein ID: WP_058490863.1
• Coordinates: 1297881..1298651 (-)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A1A5D9R9
• Locus tag: IG194_RS05920
• Protein ID: WP_043271094.1
• Coordinates: 1298652..1299020 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG194_RS05900	1294508..1295395	+	888	WP_009620572.1	metal-dependent hydrolase	-
IG194_RS05905	1295710..1297074	-	1365	WP_176707153.1	DNA recombination protein RmuC	-
IG194_RS05910	1297599..1297805	-	207	WP_058490861.1	hypothetical protein	-
IG194_RS05915	1297881..1298651	-	771	WP_058490863.1	RES family NAD+ phosphorylase	Toxin
IG194_RS05920	1298652..1299020	-	369	WP_043271094.1	DUF2384 domain-containing protein	Antitoxin
IG194_RS05925	1299299..1299733	+	435	WP_043315712.1	RcnB family protein	-
IG194_RS05930	1299740..1300171	-	432	WP_058490864.1	hypothetical protein	-
IG194_RS05935	1300300..1300782	+	483	WP_058490866.1	GreA/GreB family elongation factor	-
IG194_RS05940	1300854..1301195	+	342	WP_009620588.1	carboxymuconolactone decarboxylase family protein	-
IG194_RS05945	1301287..1301658	+	372	WP_058490868.1	hypothetical protein	-
IG194_RS05950	1301646..1302695	-	1050	WP_192353643.1	diguanylate cyclase	-
IG194_RS05955	1302989..1303825	+	837	WP_058490871.1	5'-nucleotidase, lipoprotein e(P4) family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (69-212)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 28833.97 Da
• Isoelectric Point: 6.7540

>T173382 WP_058490863.1 NZ_CP062122:c1298651-1297881 [Pseudomonas sp. ADPe]
MALDAGAELWRECRGEQAIAPLRGKLVRLVESQEQVATLQLVDTLEEQALLEELIETSKPHLPPSTETLHYLLKTPFRYP
PLRWGSRFGRRHEPSLFYAALRLETAMAEAAYYRFVLWEGMASPPPSGRILSEHASFEARFQVQRGIRLQAPPFDSYAER
LQDPQDYRLTQALGSAMRAAAVEAFEYRSARCPEGGLNAALFVPSAFVDKRPRNLMPWLCETTADYVAFKHAQVPGAPRL
FPRAGFLVEGDLPHPA

Nucleotide

• Length: 771 bp

>T173382 NZ_CP080155:4710100-4710477 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13395.70 Da
• Isoelectric Point: 10.8284

>AT173382 WP_043271094.1 NZ_CP062122:c1299020-1298652 [Pseudomonas sp. ADPe]
MSALIRETPSADLVLAKAVLAAREQLGMTQQELAAIVGVDRSAVSRWKSGGLRVGSKTGELALLLVRVYRALFALFGGNL
EDMRHFLRTPNRHLSGVPLQRMEQVQGLVQVVEYLDAIRGKI

Nucleotide

• Length: 369 bp

>AT173382 NZ_CP080155:4709679-4710053 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A1A5DAJ3

Antitoxin

• AlphaFold DB: A0A1A5D9R9