Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1284540..1285979 Replicon chromosome
Accession NZ_CP062122
Organism Pseudomonas sp. ADPe

Toxin (Protein)


Gene name - Uniprot ID W5IXK4
Locus tag IG194_RS05875 Protein ID WP_009620564.1
Coordinates 1285410..1285979 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1A5DB74
Locus tag IG194_RS05870 Protein ID WP_058490851.1
Coordinates 1284540..1285400 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG194_RS05845 1279888..1281117 - 1230 WP_009616908.1 YihY family inner membrane protein -
IG194_RS05850 1281231..1281584 + 354 WP_043267555.1 arsenate reductase (glutaredoxin) -
IG194_RS05855 1281581..1282177 + 597 WP_058490847.1 NAD(P)H:quinone oxidoreductase -
IG194_RS05860 1282178..1282597 + 420 WP_009616905.1 DUF2069 domain-containing protein -
IG194_RS05865 1283160..1284245 + 1086 WP_083540414.1 IS110 family transposase -
IG194_RS05870 1284540..1285400 - 861 WP_058490851.1 AraC family transcriptional regulator Antitoxin
IG194_RS05875 1285410..1285979 - 570 WP_009620564.1 GNAT family N-acetyltransferase Toxin
IG194_RS05880 1286230..1289706 + 3477 WP_058490853.1 hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1283142..1284245 1103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(14-146)

Antitoxin

DNA binding HTH domain, AraC-type

(197-274)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21064.37 Da        Isoelectric Point: 10.2120

>T173381 WP_009620564.1 NZ_CP062122:c1285979-1285410 [Pseudomonas sp. ADPe]
MFRPSPITLQRGALRLEPMVEADVPDLVALAEANREALKFMSAPQRPDWYRNSLAEQREGRALPLVVRLGNQLVGTTRFM
DFLPALPACEIGGTWLDAAQHGTGLNASIKYLMLRQAFDNWKMVRVQLKTAASNLRSQRAIEKLGAVREGVLRNHRRLAG
GRLDDSVLYSITDLEWPQVKAALEAGFIG

Download         Length: 570 bp

>T173381 NZ_CP080155:4603601-4604011 [Escherichia coli]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACAGGCCTGATGACACGTAA
TAACTACAGAATGGTAAATAACATTACCCTGGGTAGCATCCGGGGGCGAAACGATGAAACTTTCCCTGACGCTGGAAGCC
GACAGCATTAA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31636.99 Da        Isoelectric Point: 8.7317

>AT173381 WP_058490851.1 NZ_CP062122:c1285400-1284540 [Pseudomonas sp. ADPe]
MPLDSAHGERTRFWRAQELGGLELLHARFIEQRFAPHVHEGFALVLIEQGAQRFRHRGAEHLAPSGSLVLINPDEVHTGS
KAHEAGWLYRGFYPEIGQVGSVLDELELGGRGLPTFDASVLHDPELSRAFLHVHRLLESNASSLERQTCWREALLLLFQR
HARVPEARPAGQEPQAVARARELLAARLVEPPSLEELAAAVNLSPFHFARVFRKATGLPPHAWIKQRRLEQARALLKGGC
APASVAAQLGYADQSHLSRQFKQAYGVAPGEYRQACGRSGLPPGNL

Download         Length: 861 bp

>AT173381 NZ_CP080155:4603142-4603510 [Escherichia coli]
GTGTCAGACACACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGCATCAGAGGCCGGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5DB72

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5DB74

References