Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 137250..137781 Replicon plasmid pSR8
Accession NZ_CP062120
Organism Aminobacter sp. SR38

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag IG197_RS35725 Protein ID WP_011114071.1
Coordinates 137250..137531 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag IG197_RS35730 Protein ID WP_011114070.1
Coordinates 137518..137781 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG197_RS35695 133707..133988 - 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin -
IG197_RS35700 133975..134238 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IG197_RS35705 134411..134839 + 429 WP_011114069.1 antirestriction protein -
IG197_RS35710 135489..135752 - 264 Protein_141 type II toxin-antitoxin system YafQ family toxin -
IG197_RS35715 135739..136002 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IG197_RS35720 136175..136603 + 429 WP_011114069.1 antirestriction protein -
IG197_RS35725 137250..137531 - 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
IG197_RS35730 137518..137781 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IG197_RS35735 137954..138382 + 429 WP_011114069.1 antirestriction protein -
IG197_RS35740 138426..138641 + 216 Protein_147 hypothetical protein -
IG197_RS35745 138654..139862 + 1209 WP_011114068.1 hypothetical protein -
IG197_RS35750 139879..140136 + 258 WP_011114067.1 hypothetical protein -
IG197_RS35755 140294..140530 + 237 WP_011114066.1 stable inheritance protein KleA -
IG197_RS35760 140739..141065 + 327 WP_011114065.1 hypothetical protein -
IG197_RS35765 141067..141396 + 330 WP_011114064.1 DUF2761 domain-containing protein -
IG197_RS35770 141502..141810 + 309 WP_011114062.1 KorA protein -
IG197_RS35775 141807..142571 + 765 WP_011114061.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..197271 197271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T173379 WP_011114071.1 NZ_CP062120:c137531-137250 [Aminobacter sp. SR38]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T173379 NZ_CP080155:4215394-4215546 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT173379 WP_011114070.1 NZ_CP062120:c137781-137518 [Aminobacter sp. SR38]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT173379 NZ_CP080155:c4215345-4215288 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References