Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 133707..134238 Replicon plasmid pSR8
Accession NZ_CP062120
Organism Aminobacter sp. SR38

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag IG197_RS35695 Protein ID WP_011114071.1
Coordinates 133707..133988 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag IG197_RS35700 Protein ID WP_011114070.1
Coordinates 133975..134238 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG197_RS35675 129589..130092 + 504 WP_192321903.1 ring-opening amidohydrolase -
IG197_RS35680 129989..130624 + 636 Protein_135 Tn3 family transposase -
IG197_RS35685 130768..130947 + 180 Protein_136 Tn3 family transposase -
IG197_RS35690 131175..132197 - 1023 WP_192321175.1 IS110 family transposase -
IG197_RS35695 133707..133988 - 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
IG197_RS35700 133975..134238 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IG197_RS35705 134411..134839 + 429 WP_011114069.1 antirestriction protein -
IG197_RS35710 135489..135752 - 264 Protein_141 type II toxin-antitoxin system YafQ family toxin -
IG197_RS35715 135739..136002 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IG197_RS35720 136175..136603 + 429 WP_011114069.1 antirestriction protein -
IG197_RS35725 137250..137531 - 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin -
IG197_RS35730 137518..137781 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IG197_RS35735 137954..138382 + 429 WP_011114069.1 antirestriction protein -
IG197_RS35740 138426..138641 + 216 Protein_147 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..197271 197271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T173378 WP_011114071.1 NZ_CP062120:c133988-133707 [Aminobacter sp. SR38]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T173378 NZ_CP080155:3728305-3728523 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT173378 WP_011114070.1 NZ_CP062120:c134238-133975 [Aminobacter sp. SR38]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT173378 NZ_CP080155:3727905-3728279 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References