Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 3053..3584 Replicon plasmid pSR8
Accession NZ_CP062120
Organism Aminobacter sp. SR38

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag IG197_RS35020 Protein ID WP_011114071.1
Coordinates 3053..3334 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag IG197_RS35025 Protein ID WP_011114070.1
Coordinates 3321..3584 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG197_RS35005 177..331 + 155 Protein_0 Tn3 family transposase -
IG197_RS35010 521..1592 - 1072 Protein_1 IS110 family transposase -
IG197_RS35015 1497..1757 + 261 WP_192321923.1 hypothetical protein -
IG197_RS35020 3053..3334 - 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
IG197_RS35025 3321..3584 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IG197_RS35030 3757..4185 + 429 WP_011114069.1 antirestriction protein -
IG197_RS35035 4815..5078 - 264 Protein_6 type II toxin-antitoxin system YafQ family toxin -
IG197_RS35040 5065..5328 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IG197_RS35045 5499..5927 + 429 WP_011114069.1 antirestriction protein -
IG197_RS35050 6563..6826 - 264 Protein_9 type II toxin-antitoxin system YafQ family toxin -
IG197_RS35055 6813..7076 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IG197_RS35060 7246..7674 + 429 WP_011114069.1 antirestriction protein -
IG197_RS35065 7674..7937 + 264 WP_011296181.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..197271 197271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T173377 WP_011114071.1 NZ_CP062120:c3334-3053 [Aminobacter sp. SR38]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T173377 NZ_CP080155:3266758-3267144 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT173377 WP_011114070.1 NZ_CP062120:c3584-3321 [Aminobacter sp. SR38]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT173377 NZ_CP080155:3267134-3267463 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References