Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 20754..21415 Replicon plasmid pSR3
Accession NZ_CP062115
Organism Aminobacter sp. SR38

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IG197_RS31075 Protein ID WP_192320869.1
Coordinates 20754..21191 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IG197_RS31080 Protein ID WP_192320871.1
Coordinates 21188..21415 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG197_RS31045 16087..16548 + 462 Protein_17 IS6 family transposase -
IG197_RS31050 16675..18327 - 1653 WP_192316080.1 IS66 family transposase -
IG197_RS31055 18375..18719 - 345 WP_192316078.1 IS66 family insertion sequence element accessory protein TnpB -
IG197_RS31060 18716..19120 - 405 WP_192316076.1 transposase -
IG197_RS31065 19171..20362 + 1192 Protein_21 IS3 family transposase -
IG197_RS31070 20376..20669 - 294 Protein_22 IS6 family transposase -
IG197_RS31075 20754..21191 - 438 WP_192320869.1 PIN domain-containing protein Toxin
IG197_RS31080 21188..21415 - 228 WP_192320871.1 ribbon-helix-helix domain-containing protein Antitoxin
IG197_RS31085 21774..22813 - 1040 Protein_25 IS110 family transposase -
IG197_RS31090 22983..23402 + 420 Protein_26 IS6 family transposase -
IG197_RS31095 23470..23670 + 201 WP_192320873.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..170880 170880
- inside IScluster/Tn - - 16087..23294 7207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15208.38 Da        Isoelectric Point: 8.1574

>T173376 WP_192320869.1 NZ_CP062115:c21191-20754 [Aminobacter sp. SR38]
VTFLLDVNVLIALIDPGHVAHDDAHGWFKATGHAAWATCPVTENGVIRIVGNPKYPNSPGSPAVVAQIVTKLRTLHGHSF
WPDDVSLVGSGDIDAAKILTSAQVTDTYLLALAKTHGGQLASFDRKLSTAAVKGGKSALHLISAR

Download         Length: 438 bp

>T173376 NZ_CP080155:3019843-3020337 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8202.42 Da        Isoelectric Point: 6.2820

>AT173376 WP_192320871.1 NZ_CP062115:c21415-21188 [Aminobacter sp. SR38]
MRTTLAIDDDVLVAAKAMARQQDRSVGEIITDLARRSLRRPQGGGERNGIPLLSPRPDAPPVTLEMVNALRDELP

Download         Length: 228 bp

>AT173376 NZ_CP080155:3019553-3019846 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References