Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 200956..201838 Replicon plasmid pSR1
Accession NZ_CP062113
Organism Aminobacter sp. SR38

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag IG197_RS28870 Protein ID WP_192320542.1
Coordinates 200956..201474 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7W3KUD3
Locus tag IG197_RS28875 Protein ID WP_067967357.1
Coordinates 201467..201838 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG197_RS28855 197237..197608 - 372 WP_067968412.1 6-carboxytetrahydropterin synthase -
IG197_RS28860 197827..198357 + 531 WP_192320538.1 molybdopterin-dependent oxidoreductase -
IG197_RS28865 198368..200785 + 2418 WP_192320540.1 EAL domain-containing protein -
IG197_RS28870 200956..201474 - 519 WP_192320542.1 RES domain-containing protein Toxin
IG197_RS28875 201467..201838 - 372 WP_067967357.1 DUF2384 domain-containing protein Antitoxin
IG197_RS28880 202027..202704 - 678 WP_192320544.1 SMC-Scp complex subunit ScpB -
IG197_RS28885 202707..203660 - 954 WP_192320546.1 DUF1403 family protein -
IG197_RS28890 203864..205696 - 1833 WP_192320548.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..560213 560213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-165)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(22-63)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19143.81 Da        Isoelectric Point: 6.8543

>T173375 WP_192320542.1 NZ_CP062113:c201474-200956 [Aminobacter sp. SR38]
MPEAGLQKQRTLWRAFVPRWAHMPLSGEGAARFGGRWNPVGAPTLYAACELSTAWAEYNQGFVQHPALIAQLELSEARLA
DLTVAAILDELGIDARIHRCEWRSDLDDGRAPQTHLLRQRLLTEGFDGVVYPSFMSPGGSCVALWRWNGPGQPSLKVIDP
DQRLPKTQASWL

Download         Length: 519 bp

>T173375 NZ_CP080155:2851753-2851860 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13028.98 Da        Isoelectric Point: 10.2736

>AT173375 WP_067967357.1 NZ_CP062113:c201838-201467 [Aminobacter sp. SR38]
MAAQSLGMSAAHFGEARSQFLSARRVSELLGVTQADLARLVGVARNTLTARSGARKVDQALSPVVRILAMAAEMAGDESR
AAIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA

Download         Length: 372 bp

>AT173375 NZ_CP080155:c2851703-2851640 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3KUD3

References