Detailed information of TA system TA173374

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2099767..2100347
• Replicon: chromosome
• Accession: NZ_CP062112
• Organism: Aminobacter sp. SR38

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IG197_RS10280
• Protein ID: WP_192318625.1
• Coordinates: 2099964..2100347 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IG197_RS10275
• Protein ID: WP_192318624.1
• Coordinates: 2099767..2099967 (+)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG197_RS10245	2095745..2096032	-	288	WP_192318619.1	helix-turn-helix domain-containing protein	-
IG197_RS10250	2096169..2096675	-	507	WP_210346923.1	DUF2285 domain-containing protein	-
IG197_RS10255	2097034..2097297	-	264	WP_192318620.1	DUF2285 domain-containing protein	-
IG197_RS10260	2097455..2097715	-	261	WP_192318621.1	hypothetical protein	-
IG197_RS10265	2098047..2098283	+	237	WP_192318622.1	helix-turn-helix transcriptional regulator	-
IG197_RS10270	2098528..2099370	-	843	WP_192318623.1	DUF945 domain-containing protein	-
IG197_RS10275	2099767..2099967	+	201	WP_192318624.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
IG197_RS10280	2099964..2100347	+	384	WP_192318625.1	type II toxin-antitoxin system VapC family toxin	Toxin
IG197_RS10285	2100486..2100800	-	315	WP_192318627.1	DUF736 domain-containing protein	-
IG197_RS10290	2101679..2102098	-	420	WP_192318629.1	hypothetical protein	-
IG197_RS10295	2102165..2102536	-	372	WP_192318630.1	DUF2958 domain-containing protein	-
IG197_RS10300	2102533..2102877	-	345	WP_192318632.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 13880.00 Da
• Isoelectric Point: 6.4861

>T173374 WP_192318625.1 NZ_CP062112:2099964-2100347 [Aminobacter sp. SR38]
VILADTSIWIDHFRHSDAELRRVIEEDMLLCHPFVIGELALGSLRDRATVLAFLAAQRPAAVATHDEIMTMIDRHGLFSM
GIGYTDAHLLASVLLDRGSALWTRDKRLKAAADKAGAALFTPTATAN

Nucleotide

• Length: 384 bp

>T173374 NZ_CP080155:2851218-2851325 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7223.36 Da
• Isoelectric Point: 11.0968

>AT173374 WP_192318624.1 NZ_CP062112:2099767-2099967 [Aminobacter sp. SR38]
MRSTINIDDRLMEKARSLTGTKETAAIVRQALETLVRVETGKRLIALGGTMPDAKAAPRRRSEAAE

Nucleotide

• Length: 201 bp

>AT173374 NZ_CP080155:c2851165-2851104 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT