Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4683921..4684284 Replicon chromosome
Accession NZ_CP062066
Organism Xanthomonas campestris strain M28

Toxin (Protein)


Gene name EcnB Uniprot ID G0CKD4
Locus tag IFJ81_RS20485 Protein ID WP_011270059.1
Coordinates 4683921..4684055 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q8P3Z2
Locus tag IFJ81_RS20490 Protein ID WP_011038999.1
Coordinates 4684132..4684284 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFJ81_RS20465 4679185..4680837 - 1653 WP_057673525.1 M28 family peptidase -
IFJ81_RS20470 4681002..4681946 - 945 WP_057673527.1 MBL fold metallo-hydrolase -
IFJ81_RS20475 4682030..4683319 - 1290 WP_057673596.1 tryptophan--tRNA ligase -
IFJ81_RS20480 4683479..4683688 - 210 WP_011038998.1 CsbD family protein -
IFJ81_RS20485 4683921..4684055 - 135 WP_011270059.1 entericidin A/B family lipoprotein Toxin
IFJ81_RS20490 4684132..4684284 - 153 WP_011038999.1 entericidin A/B family lipoprotein Antitoxin
IFJ81_RS20495 4684395..4685318 - 924 WP_057673597.1 arginase -
IFJ81_RS20500 4685632..4686093 + 462 WP_057673529.1 roadblock/LC7 domain-containing protein -
IFJ81_RS20505 4686176..4686535 + 360 WP_011039002.1 hypothetical protein -
IFJ81_RS20510 4686638..4687555 + 918 WP_057673531.1 hypothetical protein -
IFJ81_RS20515 4687552..4688094 + 543 WP_057673534.1 GTPase -
IFJ81_RS20520 4688430..4689113 + 684 WP_050911792.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4431.27 Da        Isoelectric Point: 9.3487

>T173370 WP_011270059.1 NZ_CP062066:c4684055-4683921 [Xanthomonas campestris]
MKRAIALLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T173370 NZ_CP080155:2218331-2218434 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5173.15 Da        Isoelectric Point: 8.2782

>AT173370 WP_011038999.1 NZ_CP062066:c4684284-4684132 [Xanthomonas campestris]
MKRLLTLMVLGLFSAGMMTGCNTMAGAGKDMQGAGDKVEKTADKCSDGKC

Download         Length: 153 bp

>AT173370 NZ_CP080155:c2218472-2218201 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2XDQ0

Antitoxin

Source ID Structure
AlphaFold DB Q8P3Z2

References