Detailed information of TA system TA173366

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/StbC(antitoxin)
• Location: 1336531..1337169
• Replicon: chromosome
• Accession: NZ_CP062062
• Organism: Janthinobacterium sp. HH102

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JAB4_RS06105
• Protein ID: WP_139143048.1
• Coordinates: 1336747..1337169 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A853SYI4
• Locus tag: JAB4_RS06100
• Protein ID: WP_070219361.1
• Coordinates: 1336531..1336740 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JAB4_RS06080	1332406..1333656	-	1251	WP_175444774.1	alpha/beta hydrolase	-
JAB4_RS06085	1333874..1335112	+	1239	WP_070219358.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-
JAB4_RS06090	1335109..1335990	+	882	WP_070219359.1	ATP-binding protein	-
JAB4_RS06095	1335987..1336409	+	423	WP_070219360.1	NUDIX domain-containing protein	-
JAB4_RS06100	1336531..1336740	+	210	WP_070219361.1	hypothetical protein	Antitoxin
JAB4_RS06105	1336747..1337169	+	423	WP_139143048.1	type II toxin-antitoxin system VapC family toxin	Toxin
JAB4_RS06110	1337173..1337364	-	192	WP_034785391.1	DNA gyrase inhibitor YacG	-
JAB4_RS06115	1337383..1338138	-	756	WP_070219363.1	cell division protein ZapD	-
JAB4_RS06120	1338201..1338848	-	648	WP_070219364.1	dephospho-CoA kinase	-
JAB4_RS06125	1338871..1339740	-	870	WP_070219386.1	A24 family peptidase	-
JAB4_RS06130	1340026..1340616	-	591	WP_070219365.1	DUF2867 domain-containing protein	-
JAB4_RS06135	1340833..1341474	-	642	WP_070219366.1	DJ-1/PfpI family protein	-
JAB4_RS06140	1341608..1341997	-	390	WP_070219367.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15090.46 Da
• Isoelectric Point: 5.6428

>T173366 WP_139143048.1 NZ_CP062062:1336747-1337169 [Janthinobacterium sp. HH102]
MPMPAYLVDTDVIVAARKGSAAPAGVADFFERVAPELRYVPVQVIAQLRAGIQCSWRREAALEALALEGWLEAVLAEYAP
RLLEFDLDCALVCARLHGRSHAHGVDGQIAAMGIAYGLTVVSGRLDSFAAQGLRLENPFK

Nucleotide

• Length: 423 bp

>T173366 NZ_CP080155:c882065-881769 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7912.09 Da
• Isoelectric Point: 6.7248

>AT173366 WP_070219361.1 NZ_CP062062:1336531-1336740 [Janthinobacterium sp. HH102]
MPLTLTFTDTDELLIAALHKRARAHGRSIEDEHRDILRSALRPLPKRPLDDILRGMPDVGLDADFERRP

Nucleotide

• Length: 210 bp

>AT173366 NZ_CP080155:c881767-881372 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A853SYI4