Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4719776..4721379 Replicon chromosome
Accession NZ_CP062058
Organism Shewanella sp. WPAGA9

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IGB07_RS20190 Protein ID WP_192021939.1
Coordinates 4720057..4721379 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IGB07_RS20185 Protein ID WP_192021938.1
Coordinates 4719776..4720057 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGB07_RS20165 4715919..4716986 + 1068 WP_192021936.1 aminoglycoside phosphotransferase family protein -
IGB07_RS20170 4717021..4717704 + 684 WP_119968187.1 pyrimidine 5'-nucleotidase -
IGB07_RS20175 4717791..4718642 - 852 WP_119968188.1 mechanosensitive ion channel family protein -
IGB07_RS20180 4718908..4719540 - 633 WP_192021937.1 chromophore lyase CpcT/CpeT -
IGB07_RS20185 4719776..4720057 + 282 WP_192021938.1 helix-turn-helix domain-containing protein Antitoxin
IGB07_RS20190 4720057..4721379 + 1323 WP_192021939.1 type II toxin-antitoxin system HipA family toxin Toxin
IGB07_RS20195 4721521..4722774 + 1254 WP_192023120.1 DNA cytosine methyltransferase -
IGB07_RS20200 4723652..4724920 + 1269 WP_192023121.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49062.49 Da        Isoelectric Point: 7.0145

>T173364 WP_192021939.1 NZ_CP062058:4720057-4721379 [Shewanella sp. WPAGA9]
MATLDIYMNGYLVGEFTKSPTGSHVFQYASQWLDTPGCRPISLSMPLRAQSYIGDEVYNFFDNLLPDNVEVRNRIVARHN
AQSTQAFDLLAKVGQDSVGALQFVPHGQQALDVKTIEYKPLTKLVLENILKGYQSNIPLGMLTGEDDFRISIAGAQEKTA
LLNLDAIYKNGWCLPIKATPTTHIIKLPIGKIQSHSHTIDMTDSVENELLSMMIVREFGLAVPQCSIINTADIKALAVER
FDRKISSDSQWIMRLPQEDFCQTLNVPSAKKYESHGGPGIKQIMTYLLGSTNAEKDRRDFMKSQVLFWLLAATDGHAKNF
SLFIDAEGGYRLTPFYDILSMYPAIGGQGINIRDAKLAMGLNGTKGKKYAVDKIFPRHFIQTAKAVGFDPIVMAEILQEV
AETVDEVIKRVTARLPDDFPAHIRESILNGLTDRAKRLSM

Download         Length: 1323 bp

>T173364 NZ_CP080155:c671172-670708 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGGCAGAAGAAACCCATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10469.87 Da        Isoelectric Point: 8.5545

>AT173364 WP_192021938.1 NZ_CP062058:4719776-4720057 [Shewanella sp. WPAGA9]
MKVTNSKQLSAYLKDARLNMKLTQSKVASKVGIRQDTVSSFEQNPDSTKVETLFKILSALNLELDIKVRSTEPESQLTSD
GGKVAESHWKEEW

Download         Length: 282 bp

>AT173364 NZ_CP080155:c671507-671172 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACACC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References