Detailed information of TA system TA173363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 3024512..3025485
• Replicon: chromosome
• Accession: NZ_CP062008
• Organism: Mycolicibacterium mucogenicum DSM 44124

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A8H2PH79
• Locus tag: C1S78_RS14670
• Protein ID: WP_029118876.1
• Coordinates: 3024910..3025485 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A8H2PH69
• Locus tag: C1S78_RS14665
• Protein ID: WP_029118877.1
• Coordinates: 3024512..3024913 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1S78_RS14645	3020299..3020835	-	537	WP_138158407.1	YceI family protein	-
C1S78_RS14650	3021149..3021721	+	573	WP_029118880.1	TetR family transcriptional regulator	-
C1S78_RS14655	3021813..3023255	-	1443	WP_029118879.1	carotenoid oxygenase family protein	-
C1S78_RS14660	3023381..3024136	-	756	WP_051634652.1	class I SAM-dependent methyltransferase	-
C1S78_RS14665	3024512..3024913	+	402	WP_029118877.1	hypothetical protein	Antitoxin
C1S78_RS14670	3024910..3025485	+	576	WP_029118876.1	zeta toxin family protein	Toxin
C1S78_RS14675	3026073..3026462	-	390	Protein_2888	hypothetical protein	-
C1S78_RS14680	3026527..3027618	-	1092	WP_036429724.1	IS630 family transposase	-
C1S78_RS14685	3027905..3029011	-	1107	WP_053856326.1	IMP dehydrogenase	-
C1S78_RS14690	3029149..3029700	+	552	WP_053856325.1	YaeQ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2968225..3031498	63273

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 20991.00 Da
• Isoelectric Point: 9.3916

>T173363 WP_029118876.1 NZ_CP062008:3024910-3025485 [Mycolicibacterium mucogenicum DSM 44124]
VKRLDLVVGSNGAGKSTFVELTLAPLLPRSVFVNADEIAKQRWPADALGHAYEAARIAAATREALIEQGRSFIAETVFSH
PSKLELIDAARHAGYVVVLHIVLVPEDLAVHRVRYRVAAGGHDVPEEKIRERYRRLWALVAAAIVRVDSATIYDNSAASG
PQIVAQMSGGLSVDTPRWPSWTPEQLRSRWP

Nucleotide

• Length: 576 bp

>T173363 NZ_CP080155:148760-148945 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14155.63 Da
• Isoelectric Point: 4.9622

>AT173363 WP_029118877.1 NZ_CP062008:3024512-3024913 [Mycolicibacterium mucogenicum DSM 44124]
MSDVADRVTRVAADLFEAAAAEGARQSRSAKQQLDHWARVGRAVSTQHTASRRRVEAALAGQIDVAVLNTEEGVVFNAEV
SASIEESLARTDYGAVLASRGITTVALDEDGQIVEHRPDGTESVVGAVQSLRR

Nucleotide

• Length: 402 bp

>AT173363 NZ_CP080155:148962-149372 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA