Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2404794..2405434 Replicon chromosome
Accession NZ_CP062008
Organism Mycolicibacterium mucogenicum DSM 44124

Toxin (Protein)


Gene name vapC Uniprot ID A0A8H2PGP5
Locus tag C1S78_RS11670 Protein ID WP_053853752.1
Coordinates 2405033..2405434 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8H2PH83
Locus tag C1S78_RS11665 Protein ID WP_020101943.1
Coordinates 2404794..2405036 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1S78_RS11640 2400427..2401176 - 750 WP_053853755.1 enoyl-CoA hydratase -
C1S78_RS11645 2401248..2401514 + 267 WP_029105342.1 DUF2277 family protein -
C1S78_RS11650 2401511..2402059 + 549 WP_053853754.1 DUF1802 family protein -
C1S78_RS11655 2402048..2403691 - 1644 WP_053856373.1 CocE/NonD family hydrolase -
C1S78_RS11660 2404303..2404743 + 441 WP_191295052.1 hypothetical protein -
C1S78_RS11665 2404794..2405036 + 243 WP_020101943.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C1S78_RS11670 2405033..2405434 + 402 WP_053853752.1 type II toxin-antitoxin system VapC family toxin Toxin
C1S78_RS11675 2405466..2406041 - 576 WP_029105340.1 DUF3558 domain-containing protein -
C1S78_RS11680 2406204..2407145 + 942 WP_020101940.1 metallophosphoesterase -
C1S78_RS11685 2407142..2407801 + 660 WP_053853751.1 4'-phosphopantetheinyl transferase -
C1S78_RS11690 2407798..2408700 + 903 WP_082370994.1 tRNA pseudouridine(55) synthase TruB -
C1S78_RS11695 2408784..2409440 + 657 WP_051634579.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14248.07 Da        Isoelectric Point: 4.4540

>T173362 WP_053853752.1 NZ_CP062008:2405033-2405434 [Mycolicibacterium mucogenicum DSM 44124]
MIVDTSAIVALIADEDDVGVYARAIAAAVVPRLSAASYLECGIVLDARRDPVISTRFDDLVDSAGFVIEPVTERQARLAR
QAYRDFGKGSGHPAGLNFGDCFAYALAIDCREPLLWKGDDFGHTGVRSALESS

Download         Length: 402 bp

>T173362 NZ_CP080151:21344-21760 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8817.98 Da        Isoelectric Point: 5.0878

>AT173362 WP_020101943.1 NZ_CP062008:2404794-2405036 [Mycolicibacterium mucogenicum DSM 44124]
MALNIKDPAVHDAVKEIARITGESQAQAVATAVNDRLRRLQADDLAERLLDIARSIRSRLGPEGLPDHGELLYDEYGLPK

Download         Length: 243 bp

>AT173362 NZ_CP080151:21117-21347 [Escherichia coli]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References