Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pmenTA/darT(toxin) |
| Location | 970319..971981 | Replicon | chromosome |
| Accession | NZ_CP062006 | ||
| Organism | Brevundimonas pondensis strain LVF1 | ||
Toxin (Protein)
| Gene name | pmenT | Uniprot ID | - |
| Locus tag | IFE19_RS04885 | Protein ID | WP_081461864.1 |
| Coordinates | 970319..970921 (+) | Length | 201 a.a. |
Antitoxin (Protein)
| Gene name | pmenA | Uniprot ID | A0A7Y8F4G6 |
| Locus tag | IFE19_RS04890 | Protein ID | WP_003164995.1 |
| Coordinates | 970932..971981 (+) | Length | 350 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IFE19_RS04860 (IFE19_04870) | 965713..966240 | - | 528 | WP_218650374.1 | signal peptidase II | - |
| IFE19_RS04865 (IFE19_04875) | 966638..967255 | + | 618 | WP_003165001.1 | cation transporter | - |
| IFE19_RS04870 (IFE19_04880) | 967500..968080 | + | 581 | Protein_966 | DNA repair protein RadC | - |
| IFE19_RS04875 (IFE19_04885) | 968092..968601 | + | 510 | WP_040345450.1 | hypothetical protein | - |
| IFE19_RS04880 (IFE19_04890) | 968769..970037 | + | 1269 | WP_178826586.1 | Swt1 family HEPN domain-containing protein | - |
| IFE19_RS04885 (IFE19_04895) | 970319..970921 | + | 603 | WP_081461864.1 | DUF4433 domain-containing protein | Toxin |
| IFE19_RS04890 (IFE19_04900) | 970932..971981 | + | 1050 | WP_003164995.1 | macro domain-containing protein | Antitoxin |
| IFE19_RS04895 (IFE19_04905) | 972171..972917 | - | 747 | WP_040345443.1 | arsenical resistance protein ArsH | - |
| IFE19_RS04900 (IFE19_04910) | 972914..973354 | - | 441 | WP_178826584.1 | arsenic resistance N-acetyltransferase ArsN2 | - |
| IFE19_RS04905 (IFE19_04915) | 973354..974439 | - | 1086 | WP_207826182.1 | ACR3 family arsenite efflux transporter | - |
| IFE19_RS04910 (IFE19_04920) | 974439..974861 | - | 423 | WP_076222555.1 | arsenate reductase (glutaredoxin) | - |
| IFE19_RS04915 (IFE19_04925) | 974869..975204 | - | 336 | WP_076222553.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| IFE19_RS04920 (IFE19_04930) | 975487..975921 | + | 435 | WP_207826185.1 | CBS domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 942953..978561 | 35608 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 201 a.a. Molecular weight: 22015.96 Da Isoelectric Point: 7.8141
>T173360 WP_081461864.1 NZ_CP062006:970319-970921 [Brevundimonas pondensis]
MTHIGNLDEILAKGALSSTARLQAADARYNNIAYSSIQAQRAARQVPCGPGGCLHDYVPFYFTTRSPMLYTIHRGNVPCE
GGQGALVHLVSTAQKVVEAGLGFAFTDGHGIMTYSSFFDDLGRLGEVDWDVVGSRQWADTLEDGDRKRRKQAEFLVRDAF
PVTLLSGLAVQSAARKAEVEALLERRGVRMKVVEKSAWYY
MTHIGNLDEILAKGALSSTARLQAADARYNNIAYSSIQAQRAARQVPCGPGGCLHDYVPFYFTTRSPMLYTIHRGNVPCE
GGQGALVHLVSTAQKVVEAGLGFAFTDGHGIMTYSSFFDDLGRLGEVDWDVVGSRQWADTLEDGDRKRRKQAEFLVRDAF
PVTLLSGLAVQSAARKAEVEALLERRGVRMKVVEKSAWYY
Download Length: 603 bp
>T173360 NZ_CP080150:2257-2535 [Escherichia coli]
ATGGAGATATTCTGGACCATACTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGTAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGAAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGTCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG
ATGGAGATATTCTGGACCATACTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGTAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGAAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGTCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG
Antitoxin
Download Length: 350 a.a. Molecular weight: 38557.91 Da Isoelectric Point: 7.2492
>AT173360 WP_003164995.1 NZ_CP062006:970932-971981 [Brevundimonas pondensis]
MITFSKGDLLQSGAEAVINTVNCVGVMGKGIALQFKQAFPRNYDAYRRACDAGEVRLGEMFVFDTGSMINPRWIINFPTK
GHWKAKSRLSDIETGLEDLKRVILENGIRSIAVPPLGCGNGGLDWAEVEPVIRRALGDLNEVDVRLFAPGAAPKVDEMRV
GTTRPNMSRGRALVLTLLGLYGAAGYRHSLLEVQKLTYFLQAAGEDLKLGFQKYQYGPYAENLNHVLQRIEGHFIRGYGD
RSQAAEIAVLEGGRREAEAYLAGDEAARDRLDRVAELIAGFETPYGLELLSTVHWVLVHDAEASGDPDRVVQAVHAWNSR
KAAVMREPHIRTALDHLQRNGWANRAHAA
MITFSKGDLLQSGAEAVINTVNCVGVMGKGIALQFKQAFPRNYDAYRRACDAGEVRLGEMFVFDTGSMINPRWIINFPTK
GHWKAKSRLSDIETGLEDLKRVILENGIRSIAVPPLGCGNGGLDWAEVEPVIRRALGDLNEVDVRLFAPGAAPKVDEMRV
GTTRPNMSRGRALVLTLLGLYGAAGYRHSLLEVQKLTYFLQAAGEDLKLGFQKYQYGPYAENLNHVLQRIEGHFIRGYGD
RSQAAEIAVLEGGRREAEAYLAGDEAARDRLDRVAELIAGFETPYGLELLSTVHWVLVHDAEASGDPDRVVQAVHAWNSR
KAAVMREPHIRTALDHLQRNGWANRAHAA
Download Length: 1050 bp
>AT173360 NZ_CP080150:1988-2257 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTACCGGTAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTACCGGTAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|