173351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4679556..4680072 Replicon chromosome
Accession NZ_CP061975
Organism Klebsiella pneumoniae strain IR5086

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag H4I67_RS22760 Protein ID WP_009486548.1
Coordinates 4679556..4679840 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag H4I67_RS22765 Protein ID WP_002886901.1
Coordinates 4679830..4680072 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4I67_RS22735 4674973..4675281 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
H4I67_RS22740 4675366..4675539 + 174 WP_032433782.1 hypothetical protein -
H4I67_RS22745 4675542..4676285 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
H4I67_RS22750 4676642..4678780 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
H4I67_RS22755 4679088..4679552 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H4I67_RS22760 4679556..4679840 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H4I67_RS22765 4679830..4680072 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H4I67_RS22770 4680150..4682060 - 1911 WP_009486549.1 BglG family transcription antiterminator -
H4I67_RS22775 4682083..4683237 - 1155 WP_002886900.1 lactonase family protein -
H4I67_RS22780 4683304..4684044 - 741 WP_129312672.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T173351 WP_009486548.1 NZ_CP061975:c4679840-4679556 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T173351 NZ_CP080146:c3502219-3502046 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT173351 WP_002886901.1 NZ_CP061975:c4680072-4679830 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT173351 NZ_CP080146:c3502543-3502247 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References