Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4892927..4893443 Replicon chromosome
Accession NZ_CP061970
Organism Klebsiella pneumoniae strain IR5755

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag H4I70_RS24035 Protein ID WP_009486548.1
Coordinates 4892927..4893211 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag H4I70_RS24040 Protein ID WP_002886901.1
Coordinates 4893201..4893443 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4I70_RS24010 4888344..4888652 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
H4I70_RS24015 4888737..4888910 + 174 WP_002886906.1 hypothetical protein -
H4I70_RS24020 4888913..4889656 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
H4I70_RS24025 4890013..4892151 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
H4I70_RS24030 4892459..4892923 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H4I70_RS24035 4892927..4893211 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H4I70_RS24040 4893201..4893443 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H4I70_RS24045 4893521..4895431 - 1911 WP_009486549.1 BglG family transcription antiterminator -
H4I70_RS24050 4895454..4896608 - 1155 WP_020316350.1 lactonase family protein -
H4I70_RS24055 4896675..4897415 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T173332 WP_009486548.1 NZ_CP061970:c4893211-4892927 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T173332 NZ_CP080142:40111-40260 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT173332 WP_002886901.1 NZ_CP061970:c4893443-4893201 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT173332 NZ_CP080142:c40067-40006 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References