Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4714812..4715328 Replicon chromosome
Accession NZ_CP061965
Organism Klebsiella pneumoniae strain LZK001

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H4I72_RS22720 Protein ID WP_117089471.1
Coordinates 4714812..4715096 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag H4I72_RS22725 Protein ID WP_002886901.1
Coordinates 4715086..4715328 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4I72_RS22695 4710295..4710603 - 309 WP_004894688.1 PTS sugar transporter subunit IIB -
H4I72_RS22700 4710688..4710861 + 174 WP_032408826.1 hypothetical protein -
H4I72_RS22705 4710864..4711607 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
H4I72_RS22710 4711964..4714102 + 2139 WP_076027656.1 anaerobic ribonucleoside-triphosphate reductase -
H4I72_RS22715 4714344..4714808 + 465 WP_048968808.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H4I72_RS22720 4714812..4715096 - 285 WP_117089471.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H4I72_RS22725 4715086..4715328 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H4I72_RS22730 4715406..4717316 - 1911 WP_076027658.1 BglG family transcription antiterminator -
H4I72_RS22735 4717339..4718493 - 1155 WP_023159544.1 lactonase family protein -
H4I72_RS22740 4718560..4719300 - 741 WP_076027659.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11101.93 Da        Isoelectric Point: 10.4610

>T173312 WP_117089471.1 NZ_CP061965:c4715096-4714812 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKGSGYRLVHQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T173312 NZ_CP080139:c1686830-1686727 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT173312 WP_002886901.1 NZ_CP061965:c4715328-4715086 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT173312 NZ_CP080139:1686726-1686960 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References