Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4620456..4621228 Replicon chromosome
Accession NZ_CP061965
Organism Klebsiella pneumoniae strain LZK001

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag H4I72_RS22335 Protein ID WP_186971493.1
Coordinates 4620456..4620845 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag H4I72_RS22340 Protein ID WP_181959943.1
Coordinates 4620902..4621228 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4I72_RS22310 4615647..4616891 - 1245 WP_076027731.1 tRNA-guanine transglycosylase -
H4I72_RS22315 4616962..4617711 - 750 WP_077253522.1 hypothetical protein -
H4I72_RS22320 4618021..4618254 - 234 WP_023157763.1 hypothetical protein -
H4I72_RS22325 4618583..4619380 - 798 WP_186971492.1 helix-turn-helix domain-containing protein -
H4I72_RS22330 4619524..4620369 - 846 WP_117118926.1 DUF4942 domain-containing protein -
H4I72_RS22335 4620456..4620845 - 390 WP_186971493.1 TA system toxin CbtA family protein Toxin
H4I72_RS22340 4620902..4621228 - 327 WP_181959943.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H4I72_RS22345 4621286..4621507 - 222 WP_021314408.1 DUF987 domain-containing protein -
H4I72_RS22350 4621521..4622000 - 480 WP_115239227.1 DNA repair protein RadC -
H4I72_RS22355 4622012..4622455 - 444 WP_186971494.1 antirestriction protein -
H4I72_RS22360 4622536..4622784 - 249 WP_064387503.1 DUF905 domain-containing protein -
H4I72_RS22365 4622790..4623614 - 825 WP_186971495.1 DUF932 domain-containing protein -
H4I72_RS22370 4623994..4624935 - 942 WP_049109197.1 hypothetical protein -
H4I72_RS22375 4625511..4626131 + 621 WP_165470644.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14437.57 Da        Isoelectric Point: 9.9885

>T173311 WP_186971493.1 NZ_CP061965:c4620845-4620456 [Klebsiella pneumoniae]
MQTKSSPLMRAASSRPSPVYIWQTLLTSLLAHHYGLTLSDTPFIDEQVIQQHIDAGISLVDALNFIVEKHELVRTDRPGF
SILTQSPFITPIDILRARKAAGLMNRDTYKEVTAITRGQHPQVNTSGKR

Download         Length: 390 bp

>T173311 NZ_CP080139:c1323837-1322515 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12062.74 Da        Isoelectric Point: 6.7424

>AT173311 WP_181959943.1 NZ_CP061965:c4621228-4620902 [Klebsiella pneumoniae]
ISEPWWGLRRSVSPCFGARLVQEGNHLHYLADRANFNGQFCDADLRHLDQAFPVLLKQLELMLTSGELNPRHQHGVTLYA
KGLICEADTLGSHGYVYIAIYPTPVATA

Download         Length: 327 bp

>AT173311 NZ_CP080139:c1324103-1323837 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References