Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4235708..4236365 Replicon chromosome
Accession NZ_CP061965
Organism Klebsiella pneumoniae strain LZK001

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag H4I72_RS20435 Protein ID WP_002916310.1
Coordinates 4235708..4236118 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag H4I72_RS20440 Protein ID WP_002916312.1
Coordinates 4236099..4236365 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4I72_RS20415 4231708..4233441 - 1734 WP_048969163.1 single-stranded-DNA-specific exonuclease RecJ -
H4I72_RS20420 4233447..4234160 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H4I72_RS20425 4234183..4235079 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
H4I72_RS20430 4235180..4235701 + 522 WP_004144730.1 flavodoxin FldB -
H4I72_RS20435 4235708..4236118 - 411 WP_002916310.1 protein YgfX Toxin
H4I72_RS20440 4236099..4236365 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
H4I72_RS20445 4236611..4237594 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
H4I72_RS20450 4237745..4238404 - 660 WP_002916317.1 hemolysin III family protein -
H4I72_RS20455 4238568..4238879 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
H4I72_RS20460 4238929..4239657 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
H4I72_RS20465 4239776..4241209 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T173308 WP_002916310.1 NZ_CP061965:c4236118-4235708 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T173308 NZ_CP080139:c1104700-1104506 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT173308 WP_002916312.1 NZ_CP061965:c4236365-4236099 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT173308 NZ_CP080139:1104329-1104507 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References