Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4163929..4164548 Replicon chromosome
Accession NZ_CP061957
Organism Klebsiella pneumoniae strain IR5726

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H4I74_RS20555 Protein ID WP_002892050.1
Coordinates 4164330..4164548 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H4I74_RS20550 Protein ID WP_002892066.1
Coordinates 4163929..4164303 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4I74_RS20540 4159081..4160274 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H4I74_RS20545 4160297..4163443 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
H4I74_RS20550 4163929..4164303 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H4I74_RS20555 4164330..4164548 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
H4I74_RS20560 4164707..4165273 + 567 WP_002892030.1 maltose O-acetyltransferase -
H4I74_RS20565 4165245..4165385 - 141 WP_004147370.1 hypothetical protein -
H4I74_RS20570 4165406..4165876 + 471 WP_002892026.1 YlaC family protein -
H4I74_RS20575 4165851..4167302 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
H4I74_RS20580 4167403..4168101 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
H4I74_RS20585 4168098..4168238 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H4I74_RS20590 4168238..4168501 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T173260 WP_002892050.1 NZ_CP061957:4164330-4164548 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T173260 NZ_CP080126:997386-997721 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGTGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGTCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT173260 WP_002892066.1 NZ_CP061957:4163929-4164303 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT173260 NZ_CP080126:997138-997386 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References