Detailed information of TA system TA173204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 5136712..5137240
• Replicon: chromosome
• Accession: NZ_CP061944
• Organism: Pseudomonas sp. VLB120

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IF103_RS23295
• Protein ID: WP_023382869.1
• Coordinates: 5136712..5137011 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2L1HF13
• Locus tag: IF103_RS23300
• Protein ID: WP_023382870.1
• Coordinates: 5137001..5137240 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF103_RS23285	5133600..5135366	+	1767	WP_202675735.1	ATP-dependent helicase	-
IF103_RS23295	5136712..5137011	-	300	WP_023382869.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IF103_RS23300	5137001..5137240	-	240	WP_023382870.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IF103_RS23305	5137580..5139859	-	2280	WP_104882327.1	TonB-dependent siderophore receptor	-
IF103_RS23310	5140016..5140735	+	720	WP_023382872.1	response regulator transcription factor	-
IF103_RS23315	5140728..5142104	+	1377	WP_049818751.1	HAMP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	5135734..5136174	440

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11496.39 Da
• Isoelectric Point: 10.2270

>T173204 WP_023382869.1 NZ_CP061944:c5137011-5136712 [Pseudomonas sp. VLB120]
MTYSLEFDARALKEWQKLGDTVRQQLKKKLASVLLNPRVEANRLHSLPDCYKIKLRSSGYRLVYQVIEQEVVVFVVAVDK
REREQAYLKAAERVVGKTS

Nucleotide

• Length: 300 bp

>T173204 NZ_CP080119:c2794431-2794213 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9122.53 Da
• Isoelectric Point: 4.6182

>AT173204 WP_023382870.1 NZ_CP061944:c5137240-5137001 [Pseudomonas sp. VLB120]
MASINVRIDDDLKIRAYRELERLGVTPSELMRQALQYVAERGQLPFKPVLMTDEDEALLAIVRERLADPQRVRVSLDDL

Nucleotide

• Length: 240 bp

>AT173204 NZ_CP080119:c2794831-2794457 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A2L1HF13