Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3926104..3927770 Replicon chromosome
Accession NZ_CP061944
Organism Pseudomonas sp. VLB120

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag IF103_RS17590 Protein ID WP_041925530.1
Coordinates 3926104..3926952 (+) Length 283 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag IF103_RS17595 Protein ID WP_027907431.1
Coordinates 3926958..3927770 (+) Length 271 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF103_RS17565 3922098..3922943 + 846 WP_023381728.1 ABC transporter ATP-binding protein -
IF103_RS17570 3922975..3923976 + 1002 WP_023381729.1 ABC transporter substrate-binding protein -
IF103_RS17575 3924005..3924781 + 777 WP_023381730.1 ABC transporter permease -
IF103_RS17580 3924781..3925545 + 765 WP_023381731.1 SDR family oxidoreductase -
IF103_RS17585 3925560..3926099 + 540 WP_023381732.1 cupin domain-containing protein -
IF103_RS17590 3926104..3926952 + 849 WP_041925530.1 alpha/beta hydrolase Toxin
IF103_RS17595 3926958..3927770 + 813 WP_027907431.1 IclR family transcriptional regulator Antitoxin
IF103_RS17600 3927772..3928569 + 798 WP_023381735.1 SDR family oxidoreductase -
IF103_RS17605 3928562..3930244 + 1683 WP_202675511.1 thiamine pyrophosphate-binding protein -
IF103_RS17610 3930255..3931058 + 804 WP_023381737.1 aspartate dehydrogenase -
IF103_RS17615 3931069..3932559 + 1491 WP_027907430.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(38-265)

Antitoxin

Transcription regulator IclR, N-terminal

(16-65)


Sequences

Toxin        


Download         Length: 283 a.a.        Molecular weight: 29568.01 Da        Isoelectric Point: 6.8859

>T173203 WP_041925530.1 NZ_CP061944:3926104-3926952 [Pseudomonas sp. VLB120]
MIPLMPTPSLLDQRFAERLLRLDGGQLAVRQAGDGDAVVLLHGIGSGAASWLHVAMGLSERARVLAWDAPGYGQSSPLPM
AAPSARDYAGRLLQALDTLGIERCVLVGHSLGALTASAFAQACPERVNRLVLISPARGYGAVPDQGRAVRAERLHNLGQL
GIERMARERSARLLSANASAEAQAWVHWNMARLKPHGYRQAIELLCGDDLLRYAPLAVACQVHCGSADGITLPEDCAALA
AALAAPFDLIAGAGHACAIEQPDTVTGLLARALDASLTGSVL

Download         Length: 849 bp

>T173203 NZ_CP080119:2610604-2611524 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin


Download         Length: 271 a.a.        Molecular weight: 29767.26 Da        Isoelectric Point: 6.6423

>AT173203 WP_027907431.1 NZ_CP061944:3926958-3927770 [Pseudomonas sp. VLB120]
MDPLKENQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLSLPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLRLGF
EYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVTVGTRLPAHATVLGRILLADLSLAELR
ELYPEEHLEQYSPCTPKTVLELFDLVQADRLRGYVSGEGFFESTISTVAAPVRDASGQVVAALGLTIPTVQIGHVNFDNL
LGQVRGSADELSRLLNYRPGSGHVTALMRD

Download         Length: 813 bp

>AT173203 NZ_CP080119:2609835-2610617 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References