Detailed information of TA system TA173202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4115513..4116032
• Replicon: chromosome
• Accession: NZ_CP061943
• Organism: Pseudomonas chlororaphis strain PCM120

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IF690_RS18020
• Protein ID: WP_202696768.1
• Coordinates: 4115513..4115794 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1H3UB71
• Locus tag: IF690_RS18025
• Protein ID: WP_009044432.1
• Coordinates: 4115784..4116032 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF690_RS18000	4111270..4111659	-	390	WP_202696765.1	RidA family protein	-
IF690_RS18005	4112076..4112348	+	273	WP_202696766.1	hypothetical protein	-
IF690_RS18010	4113151..4113633	+	483	WP_007930527.1	acyl-CoA thioesterase	-
IF690_RS18015	4113686..4115335	+	1650	WP_202696767.1	FMN-binding glutamate synthase family protein	-
IF690_RS18020	4115513..4115794	-	282	WP_202696768.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IF690_RS18025	4115784..4116032	-	249	WP_009044432.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF690_RS18030	4116128..4116916	-	789	WP_202696769.1	helix-turn-helix transcriptional regulator	-
IF690_RS18035	4117001..4117999	+	999	WP_202696770.1	bile acid:sodium symporter	-
IF690_RS18040	4118214..4119977	+	1764	WP_202696771.1	hypothetical protein	-
IF690_RS18045	4120050..4120511	+	462	WP_202696772.1	YccF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10849.68 Da
• Isoelectric Point: 10.6993

>T173202 WP_202696768.1 NZ_CP061943:c4115794-4115513 [Pseudomonas chlororaphis]
MTYELEFSEKAWKEWQKLGPTLKEQFKKKLQERLVNPHVPADRLSGLGNAYKIKLRTAGYRLVYRVVDEVLVVTVIAVGK
RERGSVYRQASKR

Nucleotide

• Length: 282 bp

>T173202 NZ_CP080119:2343635-2343919 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8997.37 Da
• Isoelectric Point: 4.4142

>AT173202 WP_009044432.1 NZ_CP061943:c4116032-4115784 [Pseudomonas chlororaphis]
MTHVLLSNVVASISELKKNPMGTVAAGGGSSVAILNRNEPAFYCVPAKEYEAMMERLEDMELLALCRERENDPTIKVSLD
DL

Nucleotide

• Length: 249 bp

>AT173202 NZ_CP080119:2343399-2343632 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Antitoxin

• AlphaFold DB: A0A1H3UB71