Detailed information of TA system TA173200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1747455..1748077
• Replicon: chromosome
• Accession: NZ_CP061943
• Organism: Pseudomonas chlororaphis strain PCM120

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IF690_RS07895
• Protein ID: WP_202699644.1
• Coordinates: 1747895..1748077 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IF690_RS07890
• Protein ID: WP_202699643.1
• Coordinates: 1747455..1747862 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF690_RS07870	1743066..1743734	-	669	WP_202699641.1	NAD(P)-binding domain-containing protein	-
IF690_RS07875	1743831..1744721	+	891	WP_202701356.1	LysR family transcriptional regulator	-
IF690_RS07880	1744958..1746736	+	1779	WP_202699642.1	GGDEF and EAL domain-containing protein	-
IF690_RS07885	1746832..1747217	-	386	Protein_1554	GAF domain-containing protein	-
IF690_RS07890	1747455..1747862	-	408	WP_202699643.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IF690_RS07895	1747895..1748077	-	183	WP_202699644.1	type II toxin-antitoxin system HicA family toxin	Toxin
IF690_RS07905	1748623..1749507	-	885	WP_202699645.1	alpha/beta hydrolase	-
IF690_RS07910	1749859..1750551	-	693	WP_202699646.1	pseudouridine synthase	-
IF690_RS07915	1750585..1750818	-	234	WP_202699647.1	cysteine-rich CWC family protein	-
IF690_RS07920	1750811..1752298	-	1488	WP_202699648.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6813.12 Da
• Isoelectric Point: 11.4018

>T173200 WP_202699644.1 NZ_CP061943:c1748077-1747895 [Pseudomonas chlororaphis]
VNSRYLIGQIVADGWYLVRVKGSHHHFRHPSKPGLVTVPQPKKDLLRKTAISILKQALLM

Nucleotide

• Length: 183 bp

>T173200 NZ_CP080119:2107970-2108347 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14660.66 Da
• Isoelectric Point: 4.3638

>AT173200 WP_202699643.1 NZ_CP061943:c1747862-1747455 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDSAPIPPANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Nucleotide

• Length: 408 bp

>AT173200 NZ_CP080119:2107512-2107880 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA