Detailed information of TA system TA173199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1189793..1190331
• Replicon: chromosome
• Accession: NZ_CP061943
• Organism: Pseudomonas chlororaphis strain PCM120

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IF690_RS05250
• Protein ID: WP_016701683.1
• Coordinates: 1190053..1190331 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A285H8D4
• Locus tag: IF690_RS05245
• Protein ID: WP_016701682.1
• Coordinates: 1189793..1190056 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF690_RS05230	1185784..1188057	-	2274	WP_202699110.1	TonB-dependent siderophore receptor	-
IF690_RS05235	1188263..1188943	+	681	WP_016701680.1	Fe2+-dependent dioxygenase	-
IF690_RS05240	1188947..1189732	+	786	WP_202699111.1	sel1 repeat family protein	-
IF690_RS05245	1189793..1190056	+	264	WP_016701682.1	ribbon-helix-helix domain-containing protein	Antitoxin
IF690_RS05250	1190053..1190331	+	279	WP_016701683.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IF690_RS05255	1190406..1191569	-	1164	WP_007923836.1	type III PLP-dependent enzyme	-
IF690_RS05260	1192420..1193577	-	1158	WP_202699112.1	ABC transporter ATP-binding protein	-
IF690_RS05265	1193574..1194227	-	654	WP_202699113.1	ABC transporter permease	-
IF690_RS05270	1194242..1195135	-	894	WP_202699114.1	glycine betaine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10881.51 Da
• Isoelectric Point: 9.6914

>T173199 WP_016701683.1 NZ_CP061943:1190053-1190331 [Pseudomonas chlororaphis]
VRELKWTSKALSDLARLFEFLAPVNRSVAARTVQSLTQAPDTLLTNPRIGEQLEEFQPRDVRRLLVGPYEMRYEIRDATL
YILRVWHVREDR

Nucleotide

• Length: 279 bp

>T173199 NZ_CP080119:2008358-2008708 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9741.14 Da
• Isoelectric Point: 5.6088

>AT173199 WP_016701682.1 NZ_CP061943:1189793-1190056 [Pseudomonas chlororaphis]
MTATKVLTAHVPLELADKVDQMASRLERSRGWIVKQALVAWVDQEEERSRLTHEALADVDAGRVIDHQAVQAWAESLMSD
KPLPVPK

Nucleotide

• Length: 264 bp

>AT173199 NZ_CP080119:2008113-2008364 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A285H8D4