Detailed information of TA system TA173198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 543691..544304
• Replicon: chromosome
• Accession: NZ_CP061943
• Organism: Pseudomonas chlororaphis strain PCM120

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A285EYZ4
• Locus tag: IF690_RS02415
• Protein ID: WP_009041685.1
• Coordinates: 543691..543873 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IF690_RS02420
• Protein ID: WP_202701279.1
• Coordinates: 543903..544304 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF690_RS02390	538879..540843	+	1965	WP_202701277.1	choline BCCT transporter BetT	-
IF690_RS02395	540965..541222	-	258	WP_151263404.1	hypothetical protein	-
IF690_RS02400	541275..541754	-	480	WP_202698701.1	DoxX family protein	-
IF690_RS02405	541795..542535	-	741	WP_202698702.1	SDR family oxidoreductase	-
IF690_RS02410	542676..543566	+	891	WP_202698703.1	LysR family transcriptional regulator	-
IF690_RS02415	543691..543873	+	183	WP_009041685.1	type II toxin-antitoxin system HicA family toxin	Toxin
IF690_RS02420	543903..544304	+	402	WP_202701279.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IF690_RS02425	544889..545926	+	1038	WP_202698704.1	L-glyceraldehyde 3-phosphate reductase	-
IF690_RS02430	546056..546484	-	429	WP_202698705.1	type II toxin-antitoxin system VapC family toxin	-
IF690_RS02435	546481..546726	-	246	WP_028683845.1	plasmid stabilization protein	-
IF690_RS02440	546866..547705	-	840	WP_202698706.1	taurine dioxygenase	-
IF690_RS02445	547943..548782	-	840	WP_202698707.1	taurine ABC transporter permease TauC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6933.08 Da
• Isoelectric Point: 10.4588

>T173198 WP_009041685.1 NZ_CP061943:543691-543873 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Nucleotide

• Length: 183 bp

>T173198 NZ_CP080119:1905434-1905607 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14610.46 Da
• Isoelectric Point: 4.9133

>AT173198 WP_202701279.1 NZ_CP061943:543903-544304 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEIDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Nucleotide

• Length: 402 bp

>AT173198 NZ_CP080119:1905110-1905406 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A285EYZ4