Detailed information of TA system TA173197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2491187..2491746
• Replicon: chromosome
• Accession: NZ_CP061941
• Organism: Marinomonas algicola strain SM1966

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A120DEA8
• Locus tag: IEZ33_RS11500
• Protein ID: WP_046225271.1
• Coordinates: 2491468..2491746 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IEZ33_RS11495
• Protein ID: WP_191600200.1
• Coordinates: 2491187..2491471 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IEZ33_RS11445	2486242..2486808	+	567	WP_206696846.1	VTT domain-containing protein	-
IEZ33_RS11450	2487195..2487566	-	372	Protein_2229	IS110 family transposase	-
IEZ33_RS11455	2487545..2487751	-	207	Protein_2230	transposase	-
IEZ33_RS11460	2487904..2488188	+	285	WP_191600200.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
IEZ33_RS11465	2488185..2488463	+	279	WP_046225271.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
IEZ33_RS11470	2488565..2488873	-	309	WP_191600201.1	DUF1272 domain-containing protein	-
IEZ33_RS11475	2489190..2489645	-	456	WP_191600202.1	transposase	-
IEZ33_RS11480	2489744..2490091	+	348	WP_191603617.1	VTT domain-containing protein	-
IEZ33_RS11485	2490478..2490849	-	372	Protein_2236	IS110 family transposase	-
IEZ33_RS11490	2490828..2491034	-	207	Protein_2237	transposase	-
IEZ33_RS11495	2491187..2491471	+	285	WP_191600200.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IEZ33_RS11500	2491468..2491746	+	279	WP_046225271.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
IEZ33_RS11505	2491848..2492156	-	309	WP_191600201.1	DUF1272 domain-containing protein	-
IEZ33_RS11510	2492473..2492928	-	456	WP_191600203.1	transposase	-
IEZ33_RS11515	2493095..2494063	-	969	WP_191600204.1	transposase	-
IEZ33_RS11520	2494187..2494318	-	132	Protein_2243	transposase	-
IEZ33_RS11525	2494473..2495441	-	969	WP_191600205.1	transposase	-
IEZ33_RS11530	2495626..2496600	-	975	WP_191600206.1	DUF4062 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10808.44 Da
• Isoelectric Point: 4.3324

>T173197 WP_046225271.1 NZ_CP061941:2491468-2491746 [Marinomonas algicola]
MILWEEESLNDREKIFEFLYDFNPDAADKTDEIIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSAIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T173197 NZ_CP080119:1558601-1558912 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10873.16 Da
• Isoelectric Point: 8.0515

>AT173197 WP_191600200.1 NZ_CP061941:2491187-2491471 [Marinomonas algicola]
MDTRIQFRVDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKALSHDAWLTEQVNLAFEKFDSGKSSFVDHDSAKAR
MAERKAKIRSRGQQ

Nucleotide

• Length: 285 bp

>AT173197 NZ_CP080119:1558913-1559203 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Toxin

• AlphaFold DB: A0A120DEA8