Detailed information of TA system TA173195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2390682..2391445
• Replicon: chromosome
• Accession: NZ_CP061941
• Organism: Marinomonas algicola strain SM1966

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: IEZ33_RS10935
• Protein ID: WP_191600113.1
• Coordinates: 2390939..2391445 (+)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: IEZ33_RS10930
• Protein ID: WP_000212004.1
• Coordinates: 2390682..2390948 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IEZ33_RS10910	2386353..2387045	-	693	WP_191600109.1	DsbC family protein	-
IEZ33_RS10915	2387387..2388325	+	939	WP_191600110.1	Abi family protein	-
IEZ33_RS10925	2389990..2390526	+	537	WP_191600112.1	hypothetical protein	-
IEZ33_RS10930	2390682..2390948	+	267	WP_000212004.1	DUF1778 domain-containing protein	Antitoxin
IEZ33_RS10935	2390939..2391445	+	507	WP_191600113.1	GNAT family N-acetyltransferase	Toxin
IEZ33_RS10940	2391486..2391872	-	387	WP_000180225.1	hypothetical protein	-
IEZ33_RS10945	2391869..2392441	-	573	WP_191600114.1	type IV conjugative transfer system lipoprotein TraV	-
IEZ33_RS10950	2392516..2393805	-	1290	WP_191600115.1	TraB/VirB10 family protein	-
IEZ33_RS10955	2393808..2394704	-	897	WP_191603612.1	type-F conjugative transfer system secretin TraK	-
IEZ33_RS10960	2394688..2395314	-	627	WP_000667170.1	hypothetical protein	-
IEZ33_RS10965	2395311..2395592	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
IEZ33_RS10970	2395826..2396122	+	297	WP_191600116.1	HigA family addiction module antidote protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2356737..2421787	65050

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-83)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18263.97 Da
• Isoelectric Point: 7.2132

>T173195 WP_191600113.1 NZ_CP061941:2390939-2391445 [Marinomonas algicola]
MGISAPTLLADEHQINAFQCGIEELDTWLRKQALKSQKRGTARVYVVNDTDTHQVVGYYAIAMGSVSREQAFSSLRRNSP
DPIPMVILARLGVDNAYQGQGIAAGLLKDCIVRSVQAMNAVGGAGILVHAIDGSAQTFYKKFGFKESTFDPLVLMARICD
IEKSLSID

Nucleotide

• Length: 507 bp

>T173195 NZ_CP080119:c1098314-1098207 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9956.48 Da
• Isoelectric Point: 5.8580

>AT173195 WP_000212004.1 NZ_CP061941:2390682-2390948 [Marinomonas algicola]
MATKTAPINMRVLPSVRDIIDAAASLKKVDRTVFIQQAALNEAHSILAEQRDFVLEAKAFEAFDNELRAEPQTLEGMKDL
FKRKAPWE

Nucleotide

• Length: 267 bp

>AT173195 NZ_CP080119:1098363-1098428 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT