Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1412035..1412952 Replicon chromosome
Accession NZ_CP061938
Organism Bacillus velezensis strain FIO1408

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag IEN91_RS07505 Protein ID WP_025851786.1
Coordinates 1412206..1412952 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag IEN91_RS07500 Protein ID WP_003154807.1
Coordinates 1412035..1412205 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEN91_RS07465 1407265..1408887 + 1623 WP_003154821.1 pyocin knob domain-containing protein -
IEN91_RS07470 1408900..1409271 + 372 WP_003154820.1 hypothetical protein -
IEN91_RS07475 1409277..1409474 + 198 WP_003154819.1 XkdX family protein -
IEN91_RS07480 1409531..1410292 + 762 WP_058905961.1 hypothetical protein -
IEN91_RS07485 1410344..1410607 + 264 WP_032866112.1 hemolysin XhlA family protein -
IEN91_RS07490 1410621..1410884 + 264 WP_003154813.1 phage holin -
IEN91_RS07495 1410898..1411776 + 879 WP_196616559.1 N-acetylmuramoyl-L-alanine amidase -
IEN91_RS07500 1412035..1412205 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
IEN91_RS07505 1412206..1412952 - 747 WP_025851786.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
IEN91_RS07510 1413057..1414055 - 999 WP_003154805.1 inorganic phosphate transporter -
IEN91_RS07515 1414068..1414685 - 618 WP_003154804.1 DUF47 domain-containing protein -
IEN91_RS07520 1414971..1416287 - 1317 WP_003154801.1 amino acid permease -
IEN91_RS07525 1416611..1417561 + 951 WP_196616560.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1378103..1470271 92168


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29048.53 Da        Isoelectric Point: 4.7003

>T173194 WP_025851786.1 NZ_CP061938:c1412952-1412206 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CEYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

>T173194 NZ_CP080119:c1097831-1097724 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT173194 WP_003154807.1 NZ_CP061938:c1412205-1412035 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp

>AT173194 NZ_CP080119:1097888-1097945 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References