Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3813941..3814775 Replicon chromosome
Accession NZ_CP061914
Organism Escherichia coli strain SMBL

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag IE857_RS18340 Protein ID WP_079399123.1
Coordinates 3813941..3814318 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag IE857_RS18345 Protein ID WP_129541717.1
Coordinates 3814407..3814775 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE857_RS18310 3809199..3810155 + 957 WP_000121356.1 molybdenum cofactor insertion chaperone PaoD -
IE857_RS18315 3810134..3810544 + 411 WP_001111349.1 transcriptional regulator -
IE857_RS18320 3810882..3812201 + 1320 WP_000144688.1 site-specific integrase -
IE857_RS18325 3812294..3813142 - 849 WP_129541718.1 DUF4942 domain-containing protein -
IE857_RS18330 3813239..3813436 - 198 WP_000772024.1 DUF957 domain-containing protein -
IE857_RS18335 3813456..3813944 - 489 WP_032215286.1 hypothetical protein -
IE857_RS18340 3813941..3814318 - 378 WP_079399123.1 type IV toxin-antitoxin system toxin CbtA Toxin
IE857_RS18345 3814407..3814775 - 369 WP_129541717.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IE857_RS18350 3814855..3815076 - 222 WP_000692345.1 DUF987 domain-containing protein -
IE857_RS18355 3815139..3815615 - 477 WP_001186726.1 RadC family protein -
IE857_RS18360 3815631..3816116 - 486 WP_191596351.1 antirestriction protein -
IE857_RS18365 3816171..3816989 - 819 WP_191596352.1 DUF945 domain-containing protein -
IE857_RS18370 3817076..3817309 - 234 WP_191596353.1 DUF905 family protein -
IE857_RS18375 3817388..3817843 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14158.21 Da        Isoelectric Point: 7.8523

>T173162 WP_079399123.1 NZ_CP061914:c3814318-3813941 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T173162 NZ_CP080117:c4396493-4396143 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.55 Da        Isoelectric Point: 6.4652

>AT173162 WP_129541717.1 NZ_CP061914:c3814775-3814407 [Escherichia coli]
VSDTLPGTILPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFALLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT173162 NZ_CP080117:c4396738-4396487 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References