Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 808711..809543 Replicon chromosome
Accession NZ_CP061914
Organism Escherichia coli strain SMBL

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag IE857_RS03910 Protein ID WP_000854753.1
Coordinates 808711..809085 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag IE857_RS03915 Protein ID WP_001278232.1
Coordinates 809175..809543 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE857_RS03875 803876..804412 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
IE857_RS03880 804693..805253 - 561 WP_191596511.1 DUF4942 domain-containing protein -
IE857_RS03885 805311..805955 + 645 WP_191596410.1 IS66-like element accessory protein TnpA -
IE857_RS03890 805952..806299 + 348 WP_073520663.1 IS66 family insertion sequence element accessory protein TnpB -
IE857_RS03895 806319..807875 + 1557 WP_191596411.1 IS66 family transposase -
IE857_RS03900 808017..808214 - 198 WP_000839281.1 DUF957 domain-containing protein -
IE857_RS03905 808226..808714 - 489 WP_000777541.1 hypothetical protein -
IE857_RS03910 808711..809085 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
IE857_RS03915 809175..809543 - 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
IE857_RS03920 809706..809927 - 222 WP_000692353.1 DUF987 domain-containing protein -
IE857_RS03925 809996..810472 - 477 WP_086983987.1 RadC family protein -
IE857_RS03930 810488..810973 - 486 WP_029488445.1 antirestriction protein -
IE857_RS03935 811028..811846 - 819 WP_001234620.1 DUF945 domain-containing protein -
IE857_RS03940 811946..812179 - 234 WP_001119729.1 DUF905 family protein -
IE857_RS03945 812258..812713 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T173146 WP_000854753.1 NZ_CP061914:c809085-808711 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T173146 NZ_CP080117:398081-398608 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT173146 WP_001278232.1 NZ_CP061914:c809543-809175 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT173146 NZ_CP080117:397808-398074 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References