Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 2418665..2419179 Replicon chromosome
Accession NZ_CP061913
Organism Dactylosporangium vinaceum strain NRRL B-16297

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag Dvina_RS10535 Protein ID WP_223102274.1
Coordinates 2418665..2418925 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag Dvina_RS10540 Protein ID WP_246656137.1
Coordinates 2418922..2419179 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dvina_RS10520 (Dvina_10560) 2414604..2415392 + 789 WP_223102271.1 HAD-IIA family hydrolase -
Dvina_RS10525 (Dvina_10565) 2416981..2417784 - 804 WP_223102272.1 DUF3097 domain-containing protein -
Dvina_RS10530 (Dvina_10570) 2417860..2418642 + 783 WP_223102273.1 hypothetical protein -
Dvina_RS10535 (Dvina_10575) 2418665..2418925 - 261 WP_223102274.1 Txe/YoeB family addiction module toxin Toxin
Dvina_RS10540 (Dvina_10580) 2418922..2419179 - 258 WP_246656137.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Dvina_RS10545 (Dvina_10585) 2419315..2420631 - 1317 WP_223105442.1 serine hydrolase domain-containing protein -
Dvina_RS10550 (Dvina_10590) 2420726..2421160 + 435 WP_246656138.1 NfeD family protein -
Dvina_RS10555 (Dvina_10595) 2421239..2422288 + 1050 WP_223105444.1 SPFH domain-containing protein -
Dvina_RS10560 (Dvina_10600) 2422546..2424066 + 1521 WP_223102276.1 PucR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10173.56 Da        Isoelectric Point: 8.0751

>T173142 WP_223102274.1 NZ_CP061913:c2418925-2418665 [Dactylosporangium vinaceum]
VKIRFTDEGWHDYLYWQGQDRRTLRRINALIADLQRDPDGPGIGKPELLRSHLSGLRSRRIDETHRLVYTVEAGEIIILA
CRFHYE

Download         Length: 261 bp

>T173142 NZ_CP080116:4886131-4887453 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9493.58 Da        Isoelectric Point: 4.8134

>AT173142 WP_246656137.1 NZ_CP061913:c2419179-2418922 [Dactylosporangium vinaceum]
VTGAISASEARRSLFPLIERVNQDHTPIEIVSRHGNAVLVSKDDWDAIVETDYLLRTPANARHLAESIDTWRAGKATVRE
LDLDE

Download         Length: 258 bp

>AT173142 NZ_CP080116:4885865-4886131 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References