Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 168409..168971 Replicon chromosome
Accession NZ_CP061913
Organism Dactylosporangium vinaceum strain NRRL B-16297

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Dvina_RS00800 Protein ID WP_246655945.1
Coordinates 168409..168720 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Dvina_RS00805 Protein ID WP_223100460.1
Coordinates 168756..168971 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dvina_RS00780 (Dvina_00770) 163867..164148 + 282 WP_223100456.1 DUF4229 domain-containing protein -
Dvina_RS00785 (Dvina_00775) 164196..165485 + 1290 WP_223100457.1 M14 family metallopeptidase -
Dvina_RS00790 (Dvina_00780) 165463..166215 - 753 WP_223100458.1 VOC family protein -
Dvina_RS00795 (Dvina_00785) 166271..168229 - 1959 WP_246655944.1 AAA family ATPase -
Dvina_RS00800 (Dvina_00790) 168409..168720 - 312 WP_246655945.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Dvina_RS00805 (Dvina_00795) 168756..168971 - 216 WP_223100460.1 ribbon-helix-helix protein, CopG family Antitoxin
Dvina_RS00810 (Dvina_00800) 169036..169197 - 162 WP_223106263.1 hypothetical protein -
Dvina_RS00815 (Dvina_00805) 169520..169657 - 138 WP_223100461.1 hypothetical protein -
Dvina_RS00820 (Dvina_00810) 169694..169873 - 180 WP_223100462.1 hypothetical protein -
Dvina_RS00825 (Dvina_00815) 170003..170860 - 858 WP_223100463.1 hypothetical protein -
Dvina_RS00830 (Dvina_00820) 170935..171786 + 852 WP_246655946.1 menaquinone biosynthesis protein -
Dvina_RS00835 (Dvina_00825) 171819..172703 - 885 WP_223100465.1 hypothetical protein -
Dvina_RS00840 (Dvina_00830) 172951..173961 + 1011 WP_223100466.1 1,2-phenylacetyl-CoA epoxidase subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11122.86 Da        Isoelectric Point: 11.8896

>T173141 WP_246655945.1 NZ_CP061913:c168720-168409 [Dactylosporangium vinaceum]
VIGSEAAKRRPVIVVSNNAANRSAVSRGQGVVTIVPVTSNTARVYPFQVRLPADPAIGLNVESKGQAEQVRSIDVARMSQ
RLGTLPPTLMRQLDQALRLHLEL

Download         Length: 312 bp

>T173141 NZ_CP080116:4605157-4605259 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8012.87 Da        Isoelectric Point: 4.4067

>AT173141 WP_223100460.1 NZ_CP061913:c168971-168756 [Dactylosporangium vinaceum]
MKVSVSLPADDIDFVDHYARERGTTRSAVMHEAVQMLRRRDLAMDYEAANDEWVSSGEAEIWNAVTGDGLR

Download         Length: 216 bp

>AT173141 NZ_CP080116:c4605297-4605029 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References