Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1823360..1824024 Replicon chromosome
Accession NZ_CP061853
Organism Bacillus amyloliquefaciens strain MOH1-5b

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BAMOH1_RS08825 Protein ID WP_191389761.1
Coordinates 1823773..1824024 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BAMOH1_RS08820 Protein ID WP_191389759.1
Coordinates 1823360..1823776 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAMOH1_RS08800 1818634..1819038 + 405 WP_007611631.1 transcriptional repressor GlnR -
BAMOH1_RS08805 1819096..1820430 + 1335 WP_007410365.1 type I glutamate--ammonia ligase -
BAMOH1_RS08810 1820672..1820971 + 300 Protein_1681 hypothetical protein -
BAMOH1_RS08815 1822251..1822521 + 271 Protein_1682 ArpU family transcriptional regulator -
BAMOH1_RS08820 1823360..1823776 - 417 WP_191389759.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BAMOH1_RS08825 1823773..1824024 - 252 WP_191389761.1 type II toxin-antitoxin system HicA family toxin Toxin
BAMOH1_RS08830 1824211..1824648 + 438 WP_191389763.1 hypothetical protein -
BAMOH1_RS08835 1824798..1825346 + 549 Protein_1686 peptidoglycan-binding protein -
BAMOH1_RS08840 1825372..1825791 - 420 WP_191389765.1 hypothetical protein -
BAMOH1_RS08845 1825812..1826867 - 1056 WP_191389767.1 DUF4917 family protein -
BAMOH1_RS08850 1827659..1827838 + 180 WP_191389769.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(8-125)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9330.00 Da        Isoelectric Point: 10.8317

>T173126 WP_191389761.1 NZ_CP061853:c1824024-1823773 [Bacillus amyloliquefaciens]
MSSQEIIKLIEKDGWYEVRAKGSHHQFKHPTKPGTVTIPHPKKDFPKKTLKSILEGGAKIALLAKGYININNKNKNKIKG
LIN

Download         Length: 252 bp

>T173126 NZ_CP080116:c1604127-1603750 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15820.97 Da        Isoelectric Point: 4.5169

>AT173126 WP_191389759.1 NZ_CP061853:c1823776-1823360 [Bacillus amyloliquefaciens]
MKKDRYIYPALFDYDDDGITVTFPDLPGCITFGNSDEEALAMAKEAMALHLYGFEQDGDIIPEATPSREIKAEESQSIVL
IETWMPPFRHDMENAAVKKTLTIPRWMDDIAKEHKVNYSQLLQEAIKEHLGIYKNPRS

Download         Length: 417 bp

>AT173126 NZ_CP080116:c1604585-1604217 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References