Detailed information of TA system TA173126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1823360..1824024
• Replicon: chromosome
• Accession: NZ_CP061853
• Organism: Bacillus amyloliquefaciens strain MOH1-5b

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BAMOH1_RS08825
• Protein ID: WP_191389761.1
• Coordinates: 1823773..1824024 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BAMOH1_RS08820
• Protein ID: WP_191389759.1
• Coordinates: 1823360..1823776 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAMOH1_RS08800	1818634..1819038	+	405	WP_007611631.1	transcriptional repressor GlnR	-
BAMOH1_RS08805	1819096..1820430	+	1335	WP_007410365.1	type I glutamate--ammonia ligase	-
BAMOH1_RS08810	1820672..1820971	+	300	Protein_1681	hypothetical protein	-
BAMOH1_RS08815	1822251..1822521	+	271	Protein_1682	ArpU family transcriptional regulator	-
BAMOH1_RS08820	1823360..1823776	-	417	WP_191389759.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BAMOH1_RS08825	1823773..1824024	-	252	WP_191389761.1	type II toxin-antitoxin system HicA family toxin	Toxin
BAMOH1_RS08830	1824211..1824648	+	438	WP_191389763.1	hypothetical protein	-
BAMOH1_RS08835	1824798..1825346	+	549	Protein_1686	peptidoglycan-binding protein	-
BAMOH1_RS08840	1825372..1825791	-	420	WP_191389765.1	hypothetical protein	-
BAMOH1_RS08845	1825812..1826867	-	1056	WP_191389767.1	DUF4917 family protein	-
BAMOH1_RS08850	1827659..1827838	+	180	WP_191389769.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-55)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (8-125)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9330.00 Da
• Isoelectric Point: 10.8317

>T173126 WP_191389761.1 NZ_CP061853:c1824024-1823773 [Bacillus amyloliquefaciens]
MSSQEIIKLIEKDGWYEVRAKGSHHQFKHPTKPGTVTIPHPKKDFPKKTLKSILEGGAKIALLAKGYININNKNKNKIKG
LIN

Nucleotide

• Length: 252 bp

>T173126 NZ_CP080116:c1604127-1603750 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15820.97 Da
• Isoelectric Point: 4.5169

>AT173126 WP_191389759.1 NZ_CP061853:c1823776-1823360 [Bacillus amyloliquefaciens]
MKKDRYIYPALFDYDDDGITVTFPDLPGCITFGNSDEEALAMAKEAMALHLYGFEQDGDIIPEATPSREIKAEESQSIVL
IETWMPPFRHDMENAAVKKTLTIPRWMDDIAKEHKVNYSQLLQEAIKEHLGIYKNPRS

Nucleotide

• Length: 417 bp

>AT173126 NZ_CP080116:c1604585-1604217 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA