Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3026879..3028099 Replicon chromosome
Accession NZ_CP061850
Organism Pseudomonas aeruginosa strain R31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IE752_RS13845 Protein ID WP_003160088.1
Coordinates 3027521..3028099 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IE752_RS13840 Protein ID WP_003088112.1
Coordinates 3026879..3027433 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE752_RS13815 3022447..3022998 + 552 WP_003132721.1 XRE family transcriptional regulator -
IE752_RS13820 3022995..3023393 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
IE752_RS13825 3023406..3023729 - 324 WP_003102734.1 multidrug efflux SMR transporter -
IE752_RS13830 3024060..3024521 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
IE752_RS13835 3024526..3026721 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
IE752_RS13840 3026879..3027433 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
IE752_RS13845 3027521..3028099 + 579 WP_003160088.1 HD domain-containing protein Toxin
IE752_RS13850 3028208..3029395 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
IE752_RS13855 3029385..3031556 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
IE752_RS13860 3031546..3032823 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T173116 WP_003160088.1 NZ_CP061850:3027521-3028099 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T173116 NZ_CP080107:c4734150-4733779 [Enterobacter asburiae]
ATGGAGCGCATGGCGGTGTTCGATACCAATATACTCATCGATCTTTTTAATAATCGCGTTGAGGCTGCGGATGCAATTGA
TCGCACAGCTTCTCATCGAGCCATTAGTCTGATCACATGGATGGAAGTCATGGTGGGGGCCCGCAAACATGGTCACGAAG
CGAAAACTGCGACAGTGATGGGCGTATTTGAGATTATTGATATCACCCGAGATATCGCTGAAAGAAGTGTAATTTTGCGC
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCTCAGAGCAGAAGTTGCCCGTTAATCTCACGCAA
TACGAAAGACTTTTCGGGCATCACCGGGGTCGTTTCACCTTACCAGCTGTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT173116 WP_003088112.1 NZ_CP061850:3026879-3027433 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT173116 NZ_CP080107:c4734395-4734153 [Enterobacter asburiae]
ATGATTCTTTCCGCGGATCTTGATATGGGCAGAATTCTGATCGATTTGTCTGATGACGTAATTCAACGACTGGATAATCT
GAAGCAGCTGCGTAACCGGCCTCGTGCCGAATTGCTTCGGGAAGCCATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCTTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References