Detailed information of TA system TA173113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4642089..4642721
• Replicon: chromosome
• Accession: NZ_CP061849
• Organism: Chromobacterium haemolyticum strain Bb2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IEZ30_RS21450
• Protein ID: WP_019103135.1
• Coordinates: 4642305..4642721 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2T5NW37
• Locus tag: IEZ30_RS21445
• Protein ID: WP_019103136.1
• Coordinates: 4642089..4642301 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IEZ30_RS21435	4637673..4638806	+	1134	WP_081575943.1	efflux RND transporter periplasmic adaptor subunit	-
IEZ30_RS21440	4638806..4641892	+	3087	WP_191186074.1	efflux RND transporter permease subunit	-
IEZ30_RS21445	4642089..4642301	+	213	WP_019103136.1	hypothetical protein	Antitoxin
IEZ30_RS21450	4642305..4642721	+	417	WP_019103135.1	type II toxin-antitoxin system VapC family toxin	Toxin
IEZ30_RS21455	4642727..4643224	-	498	WP_191186075.1	CNP1-like family protein	-
IEZ30_RS21460	4643240..4644019	-	780	WP_019103133.1	NRDE family protein	-
IEZ30_RS21465	4644209..4644439	+	231	WP_043589636.1	sulfurtransferase TusA family protein	-
IEZ30_RS21470	4644639..4645676	+	1038	WP_191186076.1	dihydroorotase	-
IEZ30_RS21475	4645733..4646074	-	342	WP_191186077.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
IEZ30_RS21480	4646071..4646235	-	165	WP_161524382.1	hypothetical protein	-
IEZ30_RS21485	4646377..4647126	+	750	WP_043589632.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15101.20 Da
• Isoelectric Point: 6.7178

>T173113 WP_019103135.1 NZ_CP061849:4642305-4642721 [Chromobacterium haemolyticum]
VYLVDTNIVSEARKGGKANAGVLAFWRSADADSLYLSAISVGEIRRGIENLKHRGDLKQAGLLEQWLDTITQEFSQRILN
FDADCAQVWGKLMSPHPQNAVDKQIAAIALIHDLTIVTRNSGDFAGTGVKLLNPFNPI

Nucleotide

• Length: 417 bp

>T173113 NZ_CP080107:c3085272-3084919 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTCACATCGCTTGACGATACCGATCGCGCCAGCGTACTTGC
AGCACTGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCTGATACGCTTAAAGGCTCCCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCATTACGGGCGTTTTTCGCCTTTGACCCAAACCGTACTGGCATC
ATACTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGAATATATTAAAAGAGAGGGAATAG

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7840.84 Da
• Isoelectric Point: 6.4684

>AT173113 WP_019103136.1 NZ_CP061849:4642089-4642301 [Chromobacterium haemolyticum]
MANLIVRNIDDEVAAELKRRAAAHGVSAEAEHRRILRSALLAQPKRRSFAEVLANMPDVGEDADFERSRE

Nucleotide

• Length: 213 bp

>AT173113 NZ_CP080107:c3084914-3084612 [Enterobacter asburiae]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGCTAGCAACGGATAT
TTTGCTCAACATTCATCTTGCTGAGTTACGCGAGAAAGTACAAAAAACGCAGGTAGAAATGGCGCAGGCGTTGGGTATCA
GGCAACCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCTGCG
GGCGGAAAGCTGCGGCTTGATGTGGAGCTGCCGGATGGCTCGCACTATGAGTTTGTGCTGTAG

Structures

Antitoxin

• AlphaFold DB: A0A2T5NW37