Detailed information of TA system TA173111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1268861..1269463
• Replicon: chromosome
• Accession: NZ_CP061849
• Organism: Chromobacterium haemolyticum strain Bb2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0J6MTI0
• Locus tag: IEZ30_RS05740
• Protein ID: WP_043634155.1
• Coordinates: 1268861..1269043 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IEZ30_RS05745
• Protein ID: WP_107731681.1
• Coordinates: 1269053..1269463 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IEZ30_RS05720	1264272..1264985	-	714	WP_048414642.1	ABC transporter permease subunit	-
IEZ30_RS05725	1265026..1265799	-	774	WP_118266768.1	transporter substrate-binding domain-containing protein	-
IEZ30_RS05730	1265819..1266610	-	792	WP_118266770.1	ATP-binding cassette domain-containing protein	-
IEZ30_RS05735	1267165..1268577	+	1413	WP_081556622.1	sigma 54-interacting transcriptional regulator	-
IEZ30_RS05740	1268861..1269043	+	183	WP_043634155.1	type II toxin-antitoxin system HicA family toxin	Toxin
IEZ30_RS05745	1269053..1269463	+	411	WP_107731681.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IEZ30_RS05750	1269804..1270742	-	939	WP_107731682.1	PDR/VanB family oxidoreductase	-
IEZ30_RS05755	1270758..1271903	-	1146	WP_107731683.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
IEZ30_RS05760	1272140..1273021	+	882	WP_191186816.1	GlxA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6578.73 Da
• Isoelectric Point: 10.7364

>T173111 WP_043634155.1 NZ_CP061849:1268861-1269043 [Chromobacterium haemolyticum]
VTSKEVISMIEADGWYLVAAKGSHQQFKHPIKTGRVTVPHPKKDIPIGTLNSIKKQAGLK

Nucleotide

• Length: 183 bp

>T173111 NZ_CP080107:c1175346-1175128 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14891.91 Da
• Isoelectric Point: 4.6312

>AT173111 WP_107731681.1 NZ_CP061849:1269053-1269463 [Chromobacterium haemolyticum]
MYYPIAVEPGDDQHAYGVIVPDLPGCFSAGDTLDEAIRNAREAIELHLEGLVEDLDVIPLASSAQAHVGKPEFAGHLWAL
VDVDITRYLGKATKINVTLPANLLHRIDEYVASHPEYDSRSGFLAKTALEKLLCRP

Nucleotide

• Length: 411 bp

>AT173111 NZ_CP080107:c1175748-1175374 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Structures

Toxin

• AlphaFold DB: A0A0J6MTI0