Detailed information of TA system TA173110

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1256689..1257206
• Replicon: chromosome
• Accession: NZ_CP061849
• Organism: Chromobacterium haemolyticum strain Bb2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IEZ30_RS05680
• Protein ID: WP_043593771.1
• Coordinates: 1256952..1257206 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2T5NK26
• Locus tag: IEZ30_RS05675
• Protein ID: WP_019101444.1
• Coordinates: 1256689..1256952 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IEZ30_RS05655	1251790..1252317	-	528	WP_043594225.1	TIGR00645 family protein	-
IEZ30_RS05660	1252694..1254010	+	1317	WP_107733104.1	30S ribosomal protein S12 methylthiotransferase RimO	-
IEZ30_RS05665	1254984..1255508	+	525	WP_191186376.1	hypothetical protein	-
IEZ30_RS05670	1255815..1256291	+	477	WP_039755364.1	peptidylprolyl isomerase	-
IEZ30_RS05675	1256689..1256952	+	264	WP_019101444.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
IEZ30_RS05680	1256952..1257206	+	255	WP_043593771.1	Txe/YoeB family addiction module toxin	Toxin
IEZ30_RS05685	1257643..1257909	+	267	Protein_1096	peptidylprolyl isomerase	-
IEZ30_RS05690	1258124..1259056	+	933	WP_118266604.1	IS5 family transposase	-
IEZ30_RS05695	1258987..1259742	-	756	WP_191186377.1	hypothetical protein	-
IEZ30_RS05700	1259784..1260458	-	675	WP_043593767.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1258124..1259056	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10183.61 Da
• Isoelectric Point: 8.8727

>T173110 WP_043593771.1 NZ_CP061849:1256952-1257206 [Chromobacterium haemolyticum]
MQIKFDDNAWEDYLYWQQSSKPTLKRINALIKDIQRNPFEGIGKPEPLKHQFAGFWSRRIDEEHRLVYAVQSNVLTILQC
RYHY

Nucleotide

• Length: 255 bp

>T173110 NZ_CP080107:c1019282-1018941 [Enterobacter asburiae]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCATGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9740.92 Da
• Isoelectric Point: 5.6293

>AT173110 WP_019101444.1 NZ_CP061849:1256689-1256952 [Chromobacterium haemolyticum]
MKALTYSHTRQHLAEVMRQVNEDRAPVIVTTQRGEPVVIMSLADYNALEETAYLTRSPENAKRLADAAARFHSGAAKERT
LLEDEGE

Nucleotide

• Length: 264 bp

>AT173110 NZ_CP080107:c1019620-1019303 [Enterobacter asburiae]
ATGACCCACATCAACTGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGACT
GCACTATCTGGCTGACAGGGCCAGCATCACCGGCAGGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATGCCCGC
ACTTTATCCGCCAGATGGAGTCGATGCTAACCACCGGTGAACTCAGTCCCCAACACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCTGATACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2T5NK26