Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1361173..1362056 Replicon chromosome
Accession NZ_CP061848
Organism Pseudomonas asiatica strain C3

Toxin (Protein)


Gene name - Uniprot ID A0A0C1HTG7
Locus tag IE322_RS06290 Protein ID WP_015270851.1
Coordinates 1361619..1362056 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F8G488
Locus tag IE322_RS06285 Protein ID WP_013973163.1
Coordinates 1361173..1361622 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE322_RS06260 1356541..1357740 + 1200 WP_061304062.1 sugar transporter -
IE322_RS06265 1357880..1358464 - 585 WP_054572088.1 LysE family translocator -
IE322_RS06270 1358515..1359345 - 831 WP_015270854.1 AraC family transcriptional regulator -
IE322_RS06275 1359393..1360316 - 924 WP_054572087.1 LysR family transcriptional regulator -
IE322_RS06280 1360421..1361074 + 654 WP_054572086.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
IE322_RS06285 1361173..1361622 + 450 WP_013973163.1 DUF2384 domain-containing protein Antitoxin
IE322_RS06290 1361619..1362056 + 438 WP_015270851.1 RES family NAD+ phosphorylase Toxin
IE322_RS06295 1362064..1363218 - 1155 WP_054572084.1 aminotransferase class V-fold PLP-dependent enzyme -
IE322_RS06300 1363390..1364316 - 927 WP_015270849.1 LysR family transcriptional regulator -
IE322_RS06305 1364457..1365686 + 1230 WP_015270848.1 acyl-CoA dehydrogenase -
IE322_RS06310 1365764..1366828 - 1065 WP_015270847.1 TerC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-137)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15969.19 Da        Isoelectric Point: 5.1199

>T173108 WP_015270851.1 NZ_CP061848:1361619-1362056 [Pseudomonas asiatica]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPAGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSSQTELTRGLGNRFLDECSALLLPVPSAIMPSTTNYLFNPRHPQANSARLEVEDFTPDSRLF

Download         Length: 438 bp

>T173108 NZ_CP080105:1943-2281 [Klebsiella quasipneumoniae]
GTGACGACATATTGTCCAGCCAGAGGCGATGTCATTCTTTTAGATTTTAACCCTCAATCAGGGCATGAGCAGGCAGGGAA
AAGGCCTGCTCTTGTCGTTTCTGATGATTTGTTTAACCAAGTCACTGGGTTTGCTGTTGTTTGCCCCATAACTAATCAGA
TAAAAGGGTACCCTTTTGAAGTTCCTGTTGATGGGACTACTAAAACAACAGGGGTTATCTTGGCTGATCAAGTGAAGTCT
TTAGACTGGAAGGCCAGAGCGGCACGTACTGTTGATAGCGTTTCCGGCGAGACAGTAACTACAGTTGTTGATATGGTTTC
AAAAATTATTAAAGCATAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 17004.59 Da        Isoelectric Point: 6.3405

>AT173108 WP_013973163.1 NZ_CP061848:1361173-1361622 [Pseudomonas asiatica]
MLAEVLRDNGYHEYRARLHALLEIPELASDFEIHTRITHGFAATWLVKLTELGVFTPVERDQIIPLRTLKTRIERDQPLT
VEESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGFGL

Download         Length: 450 bp

>AT173108 NZ_CP080105:1716-1946 [Klebsiella quasipneumoniae]
ATGACTACGGCTATTGGTAAATGGGGTAATGGCGCTGCTTTGCGTATCCCGCAGCCGTTCATGAAGCAGCTTGGGCTTAG
TATCGGTGATGTTGTTAATTTCCGCGTCACTGAAAGGGATTTAGTAATTACTAAAGCTGGCCCGACGCTTGAAGAACTGC
TCGGACAGTGCACTGCAGAAAATCGCCATCACGAGTATCTATGTGACTCTCAAGGTAAGGAGATGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C1HTG7

Antitoxin

Source ID Structure
AlphaFold DB F8G488

References