Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 726568..727133 Replicon chromosome
Accession NZ_CP061847
Organism Lysobacter sp. CW239

Toxin (Protein)


Gene name relE Uniprot ID A0A0A0ENL2
Locus tag H2514_RS03155 Protein ID WP_036192835.1
Coordinates 726813..727133 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A0ETT7
Locus tag H2514_RS03150 Protein ID WP_036192837.1
Coordinates 726568..726825 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2514_RS03120 722028..722417 + 390 WP_036192846.1 hypothetical protein -
H2514_RS03125 722583..724262 + 1680 WP_036192843.1 urocanate hydratase -
H2514_RS03130 724476..724787 + 312 WP_052103436.1 hypothetical protein -
H2514_RS03135 724918..725145 - 228 WP_191150498.1 hypothetical protein -
H2514_RS03140 725238..725600 + 363 WP_036192840.1 hypothetical protein -
H2514_RS03145 725612..725809 + 198 WP_036192838.1 DUF2158 domain-containing protein -
H2514_RS03150 726568..726825 + 258 WP_036192837.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H2514_RS03155 726813..727133 + 321 WP_036192835.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2514_RS03160 727349..728029 + 681 WP_036192833.1 HAD family hydrolase -
H2514_RS03165 728150..728680 + 531 WP_036192831.1 tetratricopeptide repeat protein -
H2514_RS03170 728757..729119 - 363 WP_036192821.1 DUF1428 domain-containing protein -
H2514_RS03175 729300..729983 - 684 WP_036192819.1 DUF2894 domain-containing protein -
H2514_RS03180 729973..730635 - 663 WP_036192817.1 OmpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12154.17 Da        Isoelectric Point: 10.3697

>T173106 WP_036192835.1 NZ_CP061847:726813-727133 [Lysobacter sp. CW239]
MAEIVWTEPALSDLDAIADYIAIENPLAAAELVRRVIGHVEQLADHPESGSRPIELKRSRYRQIVEPPCRIFCRHDGRKV
FILHLMRSERVLRKTRLASRAKKSKG

Download         Length: 321 bp

>T173106 NZ_CP080102:c34542-34231 [Klebsiella quasipneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9644.18 Da        Isoelectric Point: 8.6058

>AT173106 WP_036192837.1 NZ_CP061847:726568-726825 [Lysobacter sp. CW239]
MRTELVTTLKRQATELLSDIERDKTPILITQHGLPSAYLVDVESYELLQQRMTVLEGIARGELAVAEGRVVSHAQAKTRL
TRWLK

Download         Length: 258 bp

>AT173106 NZ_CP080102:c34234-33815 [Klebsiella quasipneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0ENL2

Antitoxin

Source ID Structure
AlphaFold DB A0A0A0ETT7

References