Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2418534..2419193 Replicon chromosome
Accession NZ_CP061846
Organism Chryseoglobus sp. 28M-23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IE160_RS11800 Protein ID WP_179872719.1
Coordinates 2418801..2419193 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IE160_RS11795 Protein ID WP_179872718.1
Coordinates 2418534..2418797 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE160_RS11755 2413724..2414578 + 855 WP_191151214.1 DUF4097 family beta strand repeat protein -
IE160_RS11760 2414575..2415249 + 675 WP_191151215.1 PadR family transcriptional regulator -
IE160_RS11765 2415256..2415912 - 657 WP_179872714.1 hypothetical protein -
IE160_RS11770 2415996..2416436 + 441 WP_191151216.1 CrcB family protein -
IE160_RS11775 2416433..2416795 + 363 WP_191151217.1 fluoride efflux transporter CrcB -
IE160_RS11780 2416784..2416957 - 174 WP_179872716.1 hypothetical protein -
IE160_RS11785 2416960..2418063 - 1104 WP_179872717.1 NAD(P)/FAD-dependent oxidoreductase -
IE160_RS11790 2418225..2418416 + 192 WP_152583838.1 DUF3073 domain-containing protein -
IE160_RS11795 2418534..2418797 + 264 WP_179872718.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
IE160_RS11800 2418801..2419193 + 393 WP_179872719.1 type II toxin-antitoxin system VapC family toxin Toxin
IE160_RS11805 2419211..2420305 - 1095 WP_191151218.1 phosphoribosylformylglycinamidine cyclo-ligase -
IE160_RS11810 2420379..2421836 + 1458 WP_191151219.1 amidophosphoribosyltransferase -
IE160_RS11815 2421833..2422213 - 381 WP_179872722.1 hypothetical protein -
IE160_RS11820 2422249..2422641 - 393 WP_191151220.1 hypothetical protein -
IE160_RS11825 2422692..2423945 + 1254 WP_191151221.1 phosphoribosylamine--glycine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13866.86 Da        Isoelectric Point: 4.9344

>T173104 WP_179872719.1 NZ_CP061846:2418801-2419193 [Chryseoglobus sp. 28M-23]
VALYFDTSALVKLVVAEPETTALRDAARVSTVEPVSSDLTRTELLRTVRRGAPDRLVSAREVLEALTLVPVTTEVCEAAG
RLEPRTLRALDALHLASALGLGDDLEAVVTYDHRLADACRANGVAVLAPH

Download         Length: 393 bp

>T173104 NZ_CP080100:c5380-5075 [Klebsiella quasipneumoniae]
ATGCAGTTTAAGGTATATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9163.45 Da        Isoelectric Point: 8.7502

>AT173104 WP_179872718.1 NZ_CP061846:2418534-2418797 [Chryseoglobus sp. 28M-23]
MAEVGIRALKQNASAVVADAAAGETVTITDRGRPVAQLTSIAASPLQRMLANGTARRARRDLASLPAPTEAPPLTPVLAE
IRDDERY

Download         Length: 264 bp

>AT173104 NZ_CP080100:c5600-5382 [Klebsiella quasipneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References