Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1032408..1033005 Replicon chromosome
Accession NZ_CP061846
Organism Chryseoglobus sp. 28M-23

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag IE160_RS05005 Protein ID WP_152583138.1
Coordinates 1032408..1032716 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IE160_RS05010 Protein ID WP_152583106.1
Coordinates 1032706..1033005 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE160_RS04995 1028267..1028590 + 324 WP_191151820.1 putative addiction module antidote protein -
IE160_RS05000 1028630..1032229 + 3600 WP_191151983.1 TM0106 family RecB-like putative nuclease -
IE160_RS05005 1032408..1032716 + 309 WP_152583138.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IE160_RS05010 1032706..1033005 + 300 WP_152583106.1 putative addiction module antidote protein Antitoxin
IE160_RS05015 1033092..1033355 + 264 WP_152583105.1 ribbon-helix-helix protein, CopG family -
IE160_RS05020 1033393..1034706 + 1314 WP_191151821.1 plasmid pRiA4b ORF-3 family protein -
IE160_RS05025 1034814..1035242 + 429 WP_179873610.1 hypothetical protein -
IE160_RS05030 1035276..1035551 + 276 WP_179873611.1 hypothetical protein -
IE160_RS05035 1035545..1035889 + 345 WP_191151984.1 type II toxin-antitoxin system PemK/MazF family toxin -
IE160_RS05040 1035879..1036280 - 402 WP_191151822.1 DUF1622 domain-containing protein -
IE160_RS05045 1036347..1036571 + 225 Protein_990 type II toxin-antitoxin system Phd/YefM family antitoxin -
IE160_RS05050 1036727..1037662 - 936 WP_152583099.1 DUF2510 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1008722..1036280 27558


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(6-94)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11659.35 Da        Isoelectric Point: 10.1836

>T173102 WP_152583138.1 NZ_CP061846:1032408-1032716 [Chryseoglobus sp. 28M-23]
IEVRKTAIFDRWLSNVKDMRAVARILVRIDRLAQGNAGDARSIGSGLWELRIDCGPGYRVYYLRRGKALVLLLCGGDKST
QSRDIERAYELASEWRGRHHES

Download         Length: 309 bp

>T173102 NZ_CP080099:4141837-4142055 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACGTCCGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10267.51 Da        Isoelectric Point: 4.4488

>AT173102 WP_152583106.1 NZ_CP061846:1032706-1033005 [Chryseoglobus sp. 28M-23]
MKAETVSRFDAADYLPDVETAAAYLEAAIEEAGDDPAVIATALGAIARSGNLSELSRRTGISREGLYKALSAEGNPSFAT
IVKVARALGLSIEFHASAP

Download         Length: 300 bp

>AT173102 NZ_CP080099:4141436-4141810 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAATGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGATACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References