Detailed information of TA system TA173098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4697881..4699562
• Replicon: chromosome
• Accession: NZ_CP061842
• Organism: Klebsiella pneumoniae strain HC139

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486TL08
• Locus tag: IEY90_RS22895
• Protein ID: WP_032417722.1
• Coordinates: 4697881..4698798 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: IEY90_RS22900
• Protein ID: WP_004177809.1
• Coordinates: 4698804..4699562 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IEY90_RS22875	4693187..4694707	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
IEY90_RS22880	4694704..4695702	+	999	WP_002885172.1	ribose ABC transporter permease	-
IEY90_RS22885	4695733..4696674	+	942	WP_032417723.1	ABC transporter substrate-binding protein	-
IEY90_RS22890	4696749..4697756	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
IEY90_RS22895	4697881..4698798	-	918	WP_032417722.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
IEY90_RS22900	4698804..4699562	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
IEY90_RS22905	4699648..4700376	-	729	WP_004177810.1	response regulator transcription factor	-
IEY90_RS22910	4700649..4702796	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
IEY90_RS22915	4703026..4703712	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34674.07 Da
• Isoelectric Point: 5.4707

>T173098 WP_032417722.1 NZ_CP061842:c4698798-4697881 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPQESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T173098 NZ_CP080099:c1206169-1205840 [Klebsiella quasipneumoniae]
ATGAAACCTCAACCTGCAACAACTTCGCGGGCGGCGAAGCCATGCCTATCTCCTGTGGCTGTCTGGCAAATGCTGCTGAC
CCGACTGCTCGAAAAACACTATGGCCTGACGCTGAATGACACACCGTTTAGTGATGAAACCACCATACGGGAGCATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATACGGGCTTGTCCGTATCGATCGGAAAGGATTT
TCGTGGCAAGAACAAACCCCGTATATTTCCGTAGTGGATATTCTACGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT173098 WP_004177809.1 NZ_CP061842:c4699562-4698804 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT173098 NZ_CP080099:c1206507-1206190 [Klebsiella quasipneumoniae]
ATGAGCAACACCACATGGGGCCTGCAGCGGGATATCACGCCGCGCCTGGGAGCCCGCCTTGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCTGTATCACAGGTAAATTCAGTGACGCCGAATGCCAGAAGCTGGATGTGGCATTTCCGC
ACTTTATCAGCCAGATGGAATCCATGCTGATTACCGGTGAACTTAATCCCCGACACGCCCACTGCGTCATTCTGTACCAC
AACGATTTTACCTGCGAAGCCGACACTATTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGCTAA

Structures

Toxin

• AlphaFold DB: A0A486TL08

Antitoxin

• AlphaFold DB: A6TH05