Detailed information of TA system TA173097

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4531857..4532373
• Replicon: chromosome
• Accession: NZ_CP061842
• Organism: Klebsiella pneumoniae strain HC139

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IEY90_RS22060
• Protein ID: WP_040170298.1
• Coordinates: 4531857..4532141 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: IEY90_RS22065
• Protein ID: WP_002886901.1
• Coordinates: 4532131..4532373 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IEY90_RS22035	4527274..4527582	-	309	WP_004186703.1	PTS sugar transporter subunit IIB	-
IEY90_RS22040	4527667..4527840	+	174	WP_004222159.1	hypothetical protein	-
IEY90_RS22045	4527843..4528586	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
IEY90_RS22050	4528943..4531081	+	2139	WP_064148390.1	anaerobic ribonucleoside-triphosphate reductase	-
IEY90_RS22055	4531389..4531853	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IEY90_RS22060	4531857..4532141	-	285	WP_040170298.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IEY90_RS22065	4532131..4532373	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IEY90_RS22070	4532451..4534361	-	1911	WP_004152270.1	BglG family transcription antiterminator	-
IEY90_RS22075	4534384..4535538	-	1155	WP_064148391.1	lactonase family protein	-
IEY90_RS22080	4535605..4536345	-	741	WP_009486551.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11186.06 Da
• Isoelectric Point: 10.3787

>T173097 WP_040170298.1 NZ_CP061842:c4532141-4531857 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGEMVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T173097 NZ_CP080099:811334-811744 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAATGCC
GAATGGGAGATCCTCGGGACGCCGTGGATCATCAACAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATCCCGGAGAGTGGCGGGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT173097 WP_002886901.1 NZ_CP061842:c4532373-4532131 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT173097 NZ_CP080099:811087-811353 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0