Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3825571..3826190 Replicon chromosome
Accession NZ_CP061842
Organism Klebsiella pneumoniae strain HC139

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IEY90_RS18765 Protein ID WP_002892050.1
Coordinates 3825972..3826190 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IEY90_RS18760 Protein ID WP_002892066.1
Coordinates 3825571..3825945 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEY90_RS18750 3820723..3821916 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IEY90_RS18755 3821939..3825085 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
IEY90_RS18760 3825571..3825945 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IEY90_RS18765 3825972..3826190 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IEY90_RS18770 3826349..3826915 + 567 WP_002892030.1 maltose O-acetyltransferase -
IEY90_RS18775 3826887..3827027 - 141 WP_004147370.1 hypothetical protein -
IEY90_RS18780 3827048..3827518 + 471 WP_002892026.1 YlaC family protein -
IEY90_RS18785 3827493..3828944 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
IEY90_RS18790 3829045..3829743 + 699 WP_116432183.1 GNAT family N-acetyltransferase -
IEY90_RS18795 3829740..3829880 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IEY90_RS18800 3829880..3830143 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T173095 WP_002892050.1 NZ_CP061842:3825972-3826190 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T173095 NZ_CP080098:2938682-2938960 [Vibrio harveyi]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAGAAAACCGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGCGTACAACGAGATGGCA
TCCGCAGACGATTGCTTATTATTCCTGAGATTTCGATGATTGTGTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT173095 WP_002892066.1 NZ_CP061842:3825571-3825945 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT173095 NZ_CP080098:2938401-2938685 [Vibrio harveyi]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAAAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References