Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2502095..2503683 Replicon chromosome
Accession NZ_CP061842
Organism Klebsiella pneumoniae strain HC139

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IEY90_RS12350 Protein ID WP_064148190.1
Coordinates 2502095..2503417 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IEY90_RS12355 Protein ID WP_040216240.1
Coordinates 2503417..2503683 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEY90_RS12335 2497151..2499652 + 2502 WP_004184030.1 fimbrial biogenesis outer membrane usher protein -
IEY90_RS12340 2499640..2500644 + 1005 WP_064148189.1 type 1 fimbrial protein -
IEY90_RS12345 2500786..2502078 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
IEY90_RS12350 2502095..2503417 - 1323 WP_064148190.1 type II toxin-antitoxin system HipA family toxin Toxin
IEY90_RS12355 2503417..2503683 - 267 WP_040216240.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IEY90_RS12360 2503948..2504274 - 327 WP_002904788.1 hydroxyisourate hydrolase -
IEY90_RS12365 2504271..2504771 - 501 WP_032432595.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
IEY90_RS12370 2504749..2506128 - 1380 WP_192003881.1 purine permease -
IEY90_RS12375 2506474..2507628 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
IEY90_RS12380 2507609..2508532 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49201.49 Da        Isoelectric Point: 7.5357

>T173094 WP_064148190.1 NZ_CP061842:c2503417-2502095 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDSGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T173094 NZ_CP080098:2929872-2930171 [Vibrio harveyi]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCACAATCTCACTTGCGCAAGGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCGGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTTCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTTTTAGGTCAATCACAACTACCCCAGAATCACCTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9959.39 Da        Isoelectric Point: 8.6103

>AT173094 WP_040216240.1 NZ_CP061842:c2503683-2503417 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DHNTDLDW

Download         Length: 267 bp

>AT173094 NZ_CP080098:2929622-2929864 [Vibrio harveyi]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAACCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAATCAGCCAAAGAAGACTTGAACAATGGGAACACTGTTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References